Stratum corneum biomechanical properties. I. Influence of relative humidity on normal and extracted human stratum corneum.

Stratum corneum biomechanical properties. I. Influence of relative humidity on normal and extracted human stratum corneum.
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DOI：
10.1111/1523-1747.ep12292018
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发表时间：
1971
期刊：
The Journal of investigative dermatology
影响因子：
--
通讯作者：
R. Wildnauer;James W. Bothwell;Alexander B. Douglass
R. Wildnauer;James W. Bothwell;Alexander B. Douglass
中科院分区：
其他
文献类型：
--
作者：
R. Wildnauer;James W. Bothwell;Alexander B. Douglass

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力学参数，断裂功，极限断裂强度和断裂伸长率，确定从正常人角质层的应力-应变特性，在各种物理化学环境中调节。发现这些生物力学特性高度依赖于调节相对湿度（RH）和溶剂浸提历史。在0 - 100%RH范围内，未处理角质层的断裂强度下降85%，而断裂功增加600%。断裂伸长率从0%RH下的20%增加到100%RH下的190%。醚提取增加了在所有RH的断裂强度的大小，而在断裂伸长率%的RH依赖性的影响很小，与未经处理的。顺序醚-水萃取显着降低断裂伸长率在较高的RH的，而断裂强度的依赖性较低的RH比未经处理。醚-水处理的样品相对于醚提取的或未处理的样品的较低的延展性与水溶性材料的建议作用一致，所述水溶性材料负责膜柔性所必需的水结合。醚萃取对纤维断裂强度影响的机理尚不清楚。
The mechanical parameters, work of fracture, ultimate breaking strength and elongation at fracture, were determined from the stress-strain characteristics of normal human stratum corneum conditioned in various physicochemical environments. These biomechanical properties were found to be highly dependent on the conditioning relative humidity (RH) and solvent extraction history. Over the increasing 0 to 100% RH range, untreated stratum corneum breaking strength decreased 85%, while the work of fracture increased 600%. Elongation at fracture increased from 20% at 0% RH to 190% at 100% RH. Ether extraction increased the magnitude of the breaking strength at all RH's while having little influence on RH dependence of the % elongation at fracture as compared to untreated. Sequential ether-water extraction significantly decreased the fracture elongation at the higher RH's while breaking strengths were less dependent on RH than untreated. The lower extensibility of the ether-water treated samples relative to ether extracted or untreated is consistent with the suggested role of water soluble materials being responsible for the water binding necessary for membrane flexibility. The mechanism for the influence of ether extraction on the breaking strength remains unclear.