Depression of cell-mediated immunity during acute infectious mononucleosis.
Depression of cell-mediated immunity during acute infectious mononucleosis.
复制标题
急性传染性单核细胞增多症期间细胞介导的免疫抑制。
DOI：
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发表时间：
1974
影响因子：
158.5
通讯作者：
F. Kantor
中科院分区：
文献类型：
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作者：
R. Mangi;J. Niederman;J. Kelleher;J. Dwyer;A. Evans;F. Kantor
摘要为了阐明与病毒感染相关的细胞介导的免疫抑制机制，我们研究了41例传染性单核细胞增多症患者。进行皮内试验、体外淋巴细胞刺激试验和外周血T和B细胞计数。有显着的无反应性和减少淋巴细胞反应性在体外有丝分裂原和抗原在发病的第一周。这种细胞介导的免疫抑制伴随着外周血T和B细胞数量的增加。几个病人的外周血中的非典型淋巴细胞数量太多，不能完全归类为T或B细胞类型，可能代表两种类型的淋巴细胞。在这些数据的基础上，我们假设T细胞对病毒感染的反应导致抗原竞争，这是传染性单核细胞增多症期间细胞介导的免疫抑制的主要机制。（《新英格兰医学杂志》291：1149-1153，1974）
Abstract To elucidate mechanisms responsible for depression of cell-mediated immunity associated with viral infections, we studied 41 patients with infectious mononucleosis. Intradermal tests, lymphocyte stimulation in vitro and enumeration of peripheral blood T and B cells were performed. There was significant anergy and diminished lymphocyte responsiveness in vitro to mitogens and antigens during the first weeks of illness. This depression of cell-mediated immunity was accompanied by increased numbers of peripheral blood T and B cells. The numbers of atypical lymphocytes in the peripheral blood of several patients were too great to be classified as entirely T or B cells in type, and probably represent both types of lymphocytes. On the basis of these data, we hypothesize that T-cell response to viral infections results in antigenic competition, which is the major mechanism responsible for depression of cell-mediated immunity during infectious mononucleosis. (N Engl J Med 291:1149–1153, 1974)