Small-Cell Neuroendocrine Tumors: Cell State Trumps the Oncogenic Driver.

Small-Cell Neuroendocrine Tumors: Cell State Trumps the Oncogenic Driver.
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DOI:
10.1158/1078-0432.ccr-17-3646
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发表时间:
2018-04-15
期刊:
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子:
--
通讯作者:
Jänne PA
Jänne PA
中科院分区:
其他
文献类型:
--
作者:
Oser MG;Jänne PA

文献摘要

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小细胞神经内分泌癌通常起源于肺部,但也可能出现在膀胱或前列腺。在表型上,膀胱小细胞癌 (SCCB) 与小细胞肺癌 (SCLC) 有许多相似之处。目前尚不清楚 SCCB 和 SCLC 是否具有共同的基因驱动突变。
Small cell neuroendocrine cancers often originate in the lung, but can also arise in the bladder or prostate. Phenotypically, small cell carcinoma of the bladder (SCCB) shares many similarities with small cell lung cancer (SCLC). It is unknown whether SCCB and SCLC share common genetic driver mutations.