Role of Thioredoxin in Age-Related Hypertension.
Role of Thioredoxin in Age-Related Hypertension.
复制标题
硫氧还蛋白在年龄相关性高血压中的作用。
DOI：
10.1007/s11906-018-0815-9
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发表时间：
2018
影响因子：
5.6
通讯作者：
Subramani,Jaganathan
中科院分区：
文献类型：
--
作者：
Das,KumudaC;Kundumani-Sridharan,Venkatesh;Subramani,Jaganathan
虽然氧化应激和氧化还原扰动在高血压中的作用已经有了一些综述，但硫氧还蛋白（Trx），一种主要的细胞氧化还原蛋白在年龄相关性高血压中的作用仍未得到充分的综述。这篇综述的目的是让读者了解硫氧还蛋白在年龄相关性高血压中的作用。年龄相关性高血压是几种心血管疾病的主要潜在原因，因此，大多数心血管并发症患者需要加强血压管理。最近的研究表明，在人类Trx （Trx- tg）水平较高的小鼠中，与年龄相关的高血压被逆转并在很长一段时间内保持较低的水平。此外，注射人重组Trx （rhTrx）可以降低老年野生型小鼠的高血压，持续数天。注射rhTrx后，Trx-Tg小鼠和老龄野生型小鼠血压正常，一氧化氮生成增加，动脉僵硬度降低，血管舒张度增加。这些研究表明，rhTrx可能是一种潜在的治疗分子，可以逆转人类年龄相关性高血压。在高血压治疗中，通过恢复经历了年龄相关修饰的蛋白质来逆转与年龄相关的高血压在概念上是新颖的。trx通过维持血管氧化还原稳态，再生因年龄增长而氧化的关键血管调节蛋白，以及恢复因年龄变化而丧失功能的蛋白质的天然功能来逆转年龄相关性高血压。最近的研究表明，Trx是一种有希望改善或逆转老年人年龄相关性高血压的分子。
Purpose of ReviewAlthough the roles of oxidant stress and redox perturbations in hypertension have been the subject of several reviews, role of thioredoxin (Trx), a major cellular redox protein in age-related hypertension remains inadequately reviewed. The purpose of this review is to bring readers up-to-date with current understanding of the role of thioredoxin in age-related hypertension.Recent FindingsAge-related hypertension is a major underlying cause of several cardiovascular disorders, and therefore, intensive management of blood pressure is indicated in most patients with cardiovascular complications. Recent studies have shown that age-related hypertension was reversed and remained lowered for a prolonged period in mice with higher levels of human Trx (Trx-Tg). Additionally, injection of human recombinant Trx (rhTrx) decreased hypertension in aged wild-type mice that lasted for several days. Both Trx-Tg and aged wild-type mice injected with rhTrx were normotensive, showed increased NO production, decreased arterial stiffness, and increased vascular relaxation. These studies suggest that rhTrx could potentially be a therapeutic molecule to reverse age-related hypertension in humans. The reversal of age-related hypertension by restoring proteins that have undergone age-related modification is conceptually novel in the treatment of hypertension.SummaryTrx reverses age-related hypertension via maintaining vascular redox homeostasis, regenerating critical vasoregulatory proteins oxidized due to advancing age, and restoring native function of proteins that have undergone age-related modifications with loss-of function. Recent studies demonstrate that Trx is a promising molecule that may ameliorate or reverse age-related hypertension in older adults.