Highly efficient crystal red fluorescent 1,2-squaraine dyes with excellent biocompatibility and bioimaging
Highly efficient crystal red fluorescent 1,2-squaraine dyes with excellent biocompatibility and bioimaging
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DOI：
10.1016/j.dyepig.2018.10.064
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发表时间：
2019-03-01
影响因子：
4.5
通讯作者：
Wang, Hongming
中科院分区：
文献类型：
--
作者：
Cong, Zhenxing;Li, Yuanfang;Wang, Hongming
设计并合成了一类新的不对称1，2-方酸菁染料（1，2-SQs）。水热物理分析表明，这些1，2-SQs在晶体状态下显示出较强的红色荧光，而在溶液中显示出较弱的荧光，表明它们具有聚集诱导发射增强（AIEE）性质。单晶X射线衍射分析表明，晶体状态下的强荧光可归因于分子中长烷基链或大基团取代基的作用，有效地阻止了分子间的紧密接触，降低了π-π相互作用。进一步研究了SQ 4的生物相容性和细胞成像应用。结果表明，SQ 4对SMMC-7721细胞具有良好的生物相容性，具有潜在的生物成像价值。
A new family of asymmetrical 1,2-squaraine dyes (1,2-SQs) were designed and synthesized in high yields. The photophysical analysis presented that these 1,2-SQs showed strong red fluorescence in crystal state but weak fluorescence in solution, suggesting their aggregation -induced emission enhancement (AIEE) properties. Single crystals X-ray diffraction revealed that the intense fluorescence in the crystal state can be attributed to the effects of long alkyl chains or large group substituents in the molecules, which efficiently prevented the tight intermolecular contact and reduced pi-pi interactions. The biocompatibility and cell imaging applications of SQ4 were further investigated. The results demonstrated that SMMC-7721 cell can be clearly imaged by SQ4, which inferred SQ4 had excellent biocompatibility and potential value for bioimaging.