ON direction-selective ganglion cells in the mouse retina
ON direction-selective ganglion cells in the mouse retina
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DOI：
10.1113/jphysiol.2006.115857
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发表时间：
2006-10-01
影响因子：
5.5
通讯作者：
He, Shigang
中科院分区：
文献类型：
--
作者：
Sun, Wenzhi;Deng, Qiudong;He, Shigang
两种类型的神经节细胞（RGC）计算视网膜中的运动方向：ON-OFF方向选择性神经节细胞（DSGCs）和ON DSGCs。ON DSGCs的研究要少得多，主要是由于遇到率低。在这项研究中，我们研究了生理学，树突状细胞形态和突触输入的小鼠视网膜上的DSGCs。当视觉刺激在偏好零轴上来回移动时，我们发现当视觉刺激在偏好方向上移动时，ON DSGCs表现出更大的EPSC，而在相反方向或零方向上表现出更大的IPSC，这与ON-OFF DSGCs中发现的相似。这种类似的突触输入模式与其他众所周知的差异形成对比，即：速度敏感性的分布，首选方向的分布，以及轴突的不同中央投影。免疫组化染色显示，树突与胆碱能神经丛呈紧密的共成束。这些研究结果表明，胆碱能无长突细胞可能在产生方向选择性的ON DSGCs中发挥重要作用，编码运动方向的机制可能是相似的两种类型的DSGCs在视网膜中。
Two types of ganglion cells (RGCs) compute motion direction in the retina: the ON-OFF direction-selective ganglion cells (DSGCs) and the ON DSGCs. The ON DSGCs are much less studied mostly due to the low encounter rate. In this study, we investigated the physiology, dendritic morphology and synaptic inputs of the ON DSGCs in the mouse retina. When a visual stimulus moved back and forth in the preferred-null axis, we found that the ON DSGCs exhibited a larger EPSC when the visual stimulus moved in the preferred direction and a larger IPSC in the opposite, or null direction, similar to what has been found in ON-OFF DSGCs. This similar synaptic input pattern is in contrast to other well-known differences, namely: profile of velocity sensitivity, distribution of preferred directions, and different central projection of the axons. Immunohistochemical staining showed that the dendrites of ON DSGCs exhibited tight cofasciculation with the cholinergic plexus. These findings suggest that cholinergic amacrine cells may play an important role in generating direction selectivity in the ON DSGCs, and that the mechanism for coding motion direction is probably similar for the two types of DSGCs in the retina.