Mammillary body volume abnormalities in anorexia nervosa.
Mammillary body volume abnormalities in anorexia nervosa.
复制标题
神经性厌食症的乳头体体积异常。
DOI：
10.1002/eat.22573
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Feusner,JamieD
中科院分区：
文献类型：
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作者：
Khalsa,SahibS;Kumar,Rajesh;Patel,Vandan;Strober,Michael;Feusner,JamieD
ObjectiveSeveral case reports of Wernicke's Encephalopathy in anorexia nervosa (AN) caused by thiamine deficiency have described mammillary body (MB) injury, but systematic studies are lacking. Here we evaluated whether underweight and weight‐restored individuals with AN demonstrate evidence of abnormal MB morphology, via retrospective examination of a previously collected data set.MethodUsing standard‐resolution T1‐weighted magnetic resonance imaging at 3 Tesla, we measured MB volume and fornix area in a cross‐sectional study of 12 underweight AN, 20 weight‐restored AN, and 30 age‐ and sex‐matched healthy comparisons. Because of the small size of these structures, a manual tracing approach was necessary to obtain accurate measurements. A blinded expert rater manually traced MB and fornix structures in each participant.ResultsWe observed significantly smaller MB volumes in the underweight AN group. However, the weight‐restored AN group exhibited significantly larger MB volumes. The right fornix was smaller in the weight‐restored AN group only.DiscussionThese findings suggest the possibility that MB volume and fornix area could represent potential biomarkers of acute weight loss and restoration, respectively. Verification of this finding through prospective studies evaluating MB morphology, cognition, and thiamine levels longitudinally across individual illness trajectories might be warranted. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:920–929)
