Role of Heat Shock Proteins in Protection from and Pathogenesis of Infectious Diseases
Role of Heat Shock Proteins in Protection from and Pathogenesis of Infectious Diseases
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DOI：
10.1128/cmr.12.1.19
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发表时间：
1999-01
影响因子：
36.8
通讯作者：
U. Zügel;S. Kaufmann
中科院分区：
文献类型：
--
作者：
U. Zügel;S. Kaufmann
摘要
当原核细胞和真核细胞受到应激时，热休克蛋白（hsp）的合成会增加。通过增加热休克蛋白含量，细胞可保护自身免受致命攻击，这主要是因为热休克蛋白会干扰应激条件下发生的蛋白质无序展开。然而，热休克蛋白并非仅由受应激的细胞产生；一些热休克蛋白是组成性合成的，并执行重要的细胞内务管理功能。因此，热休克蛋白参与在免疫系统中起重要作用的分子的组装。由于热休克蛋白在不同物种间广泛分布且具有同源性，它们成为免疫反应的靶抗原也就不足为奇了。免疫系统频繁接触各种微生物病原体所共有的热休克蛋白保守区域，可增强抗菌免疫。然而，免疫系统长期接触宿主和病原体中相似的热休克蛋白抗原，可能会使针对这些宿主抗原的免疫反应发生转变，并促进自身免疫性疾病的发生。本综述概述了热休克蛋白在免疫中的作用，重点关注感染性疾病和自身免疫性疾病。
SUMMARY Increased synthesis of heat shock proteins (hsp) occurs in prokaryotic and eukaryotic cells when they are exposed to stress. By increasing their hsp content, cells protect themselves from lethal assaults, primarily because hsp interfere with the uncontrolled protein unfolding that occurs under stress. However, hsp are not produced only by stressed cells; some hsp are synthesized constitutively and perform important housekeeping functions. Accordingly, hsp are involved in the assembly of molecules which play important roles in the immune system. It is not surprising that due to their wide distribution and their homology among different species, hsp represent target antigens of the immune response. Frequent confrontation of the immune system with conserved regions of hsp which are shared by various microbial pathogens can potentiate antimicrobial immunity. However, long-term confrontation of the immune system with hsp antigens which are similar in the host and invaders may convert the immune response against these host antigens and promote autoimmune disease. This review provides an overview of the role of hsp in immunity with a focus on infectious and autoimmune diseases.