The gap-prepulse inhibition deficit of the cortical N1-P2 complex in patients with tinnitus: The effect of gap duration
The gap-prepulse inhibition deficit of the cortical N1-P2 complex in patients with tinnitus: The effect of gap duration
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DOI：
10.1016/j.heares.2017.03.003
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发表时间：
2017-05-01
期刊：
影响因子：
2.8
通讯作者：
Kim, Hee Chan
中科院分区：
文献类型：
--
作者：
Ku, Yunseo;Ahn, Joong Woo;Kim, Hee Chan
本研究旨在探讨耳鸣患者皮质听觉诱发电位N1-P2复合体是否存在间隙前脉冲抑制（GPI）缺陷。从 16 名耳鸣患者和 18 名年龄和听力损失匹配的无耳鸣对照中获得了对 GPI 范式强烈声音的听觉迟发反应。使用耳鸣音调匹配和不匹配频率背景噪声在 100、50 和 20 ms 间隙持续时间下评估 N1-P2 复合体的抑制程度。在耳鸣音高匹配频率背景噪声的 20 毫秒间隙条件下，只有耳鸣组表现出 N1-P2 复合体的抑制缺陷。间隙持续时间较长的两组均不存在抑制缺陷。这些发现表明，耳鸣的影响取决于提示出现时间和间隙预脉冲的持续时间。由于在相同的 20 毫秒间隙条件下两组均观察到抑制缺陷，但耳鸣音调不匹配频率背景噪声，因此本研究没有提供耳鸣填充间隙的概念证明。未来需要进一步研究不同背景频率对间隙处理的内在影响。 (C) 2017 Elsevier B.V. 保留所有权利。
The present study aimed to investigate whether gap-prepulse inhibition (GPI) deficit in patients with tinnitus occurred in the N1-P2 complex of the cortical auditory evoked potential. Auditory late responses to the intense sound of the GPI paradigm were obtained from 16 patients with tinnitus and 18 age- and hearing loss-matched controls without tinnitus. The inhibition degrees of the N1-P2 complex were assessed at 100-, 50-, and 20-ms gap durations with tinnitus-pitch-matched and non-matched frequency background noises. At the 20-ms gap condition with the tinnitus-pitch-matched frequency background noise, only the tinnitus group showed an inhibition deficit of the N1-P2 complex. The inhibition deficits were absent in both groups with longer gap durations. These findings suggested that the effect of tinnitus emerged depending on the cue onset timing and duration of the gap-prepulse. Since inhibition deficits were observed in both groups at the same 20-ms gap condition, but with the tinnitus-pitch-non-matched frequency background noise, the present study did not offer proof of concept for tinnitus filling in the gap. Additional studies on the intrinsic effects of different background frequencies on the gap processing are required in the future. (C) 2017 Elsevier B.V. All rights reserved.