Hair cell regeneration from inner ear progenitors in the mammalian cochlea.
Hair cell regeneration from inner ear progenitors in the mammalian cochlea.
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DOI：
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发表时间：
2020-06
影响因子：
1.8
通讯作者：
Shasha Zhang;Ruiying Qiang;Ying Dong;Y. Zhang;Yin Chen;Han Zhou;Xia Gao;R. Chai
中科院分区：
文献类型：
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作者：
Shasha Zhang;Ruiying Qiang;Ying Dong;Y. Zhang;Yin Chen;Han Zhou;Xia Gao;R. Chai
耳蜗毛细胞（HC）是听觉系统的机械感受器，由于这些细胞不能在成年哺乳动物中自发再生，因此HC损伤导致的听力损失是永久性的。然而，新生小鼠的耳蜗中含有一些祖细胞，这些祖细胞在体内产生新HC的能力有限。在这里，我们审查的调控因素，信号通路，和表观遗传因素，已报告发挥作用，在新生儿哺乳动物耳蜗HC再生。
Cochlear hair cells (HCs) are the mechanoreceptors of the auditory system, and because these cells cannot be spontaneously regenerated in adult mammals, hearing loss due to HC damage is permanent. However, cochleae of neonatal mice harbor some progenitor cells that retain limited ability to give rise to new HCs in vivo. Here we review the regulatory factors, signaling pathways, and epigenetic factors that have been reported to play roles in HC regeneration in the neonatal mammalian cochlea.