Characterization of a Feline Influenza A(H7N2) Virus.
Characterization of a Feline Influenza A(H7N2) Virus.
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DOI：
10.3201/eid2401.171240
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发表时间：
2018-01
影响因子：
11.8
通讯作者：
Kawaoka Y
中科院分区：
文献类型：
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作者：
Hatta M;Zhong G;Gao Y;Nakajima N;Fan S;Chiba S;Deering KM;Ito M;Imai M;Kiso M;Nakatsu S;Lopes TJ;Thompson AJ;McBride R;Suarez DL;Macken CA;Sugita S;Neumann G;Hasegawa H;Paulson JC;Toohey-Kurth KL;Kawaoka Y
2016年12月至2017年2月，美国纽约州动物收容所约500只猫感染H7N2亚型甲型流感病毒，表明病毒在猫中传播。治疗这些动物的一名兽医也感染了猫流感A（H7N2）病毒，并出现呼吸道症状。为了了解这些猫H7N2病毒在哺乳动物中的致病性和传播力，我们对它们进行了体内和体外鉴定。猫H7N2亚型病毒在小鼠、雪貂和猫的呼吸器官中复制，但不会造成严重损害。在雪貂和猫中检测到猫H7N2亚型病毒的直接接触传播；在猫中，暴露的动物也通过呼吸道飞沫传播感染。这些结果表明，H7N2亚型猫病毒可以在猫中传播，也可以感染人类。因此，猫H7N2病毒的爆发可能对公众健康构成威胁。
During December 2016–February 2017, influenza A viruses of the H7N2 subtype infected ≈500 cats in animal shelters in New York, NY, USA, indicating virus transmission among cats. A veterinarian who treated the animals also became infected with feline influenza A(H7N2) virus and experienced respiratory symptoms. To understand the pathogenicity and transmissibility of these feline H7N2 viruses in mammals, we characterized them in vitro and in vivo. Feline H7N2 subtype viruses replicated in the respiratory organs of mice, ferrets, and cats without causing severe lesions. Direct contact transmission of feline H7N2 subtype viruses was detected in ferrets and cats; in cats, exposed animals were also infected via respiratory droplet transmission. These results suggest that the feline H7N2 subtype viruses could spread among cats and also infect humans. Outbreaks of the feline H7N2 viruses could, therefore, pose a risk to public health.