IMMUNOGENETIC STUDIES OF SPONTANEOUS-ABORTION IN MICE .2. ANTI-ABORTIVE EFFECTS ARE INDEPENDENT OF SYSTEMIC REGULATORY MECHANISMS
IMMUNOGENETIC STUDIES OF SPONTANEOUS-ABORTION IN MICE .2. ANTI-ABORTIVE EFFECTS ARE INDEPENDENT OF SYSTEMIC REGULATORY MECHANISMS
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DOI：
10.1016/0008-8749(86)90306-0
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发表时间：
1986-04-01
影响因子：
4.3
通讯作者：
KIGER, N
中科院分区：
文献类型：
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作者：
BOBE, P;CHAOUAT, G;KIGER, N
CBA/J雌性（H-2k）与DBA 2/J雄性（H-2d）交配显示出较高的胎仔吸收率。用BALB/c J（H-2d）雄性（而不是CBA/J或DBA/2/J）的脾细胞预处理CBA/J雌性可提高胎儿存活率。类似地，九个重组近交系中的三个（将BALB/c和DBA 2基因组重组为纯合状态）具有与BALB/c亲本相似的抗流产作用。先前的研究表明，BALB/c预处理触发CBA/J雌性小鼠脾脏中抑制细胞和血清中IgG 1抗H-2d抗体的出现。CBA/J预免疫后的这两个免疫学参数的研究表明，局部宫内免疫调节是异体妊娠成功或失败的决定因素。
CBA/J females (H-2k) mated with DBA2/J males (H-2d) exhibit a high rate of fetal resorption. Fetal survival has been improved by pretreatment of CBA/J females wth spleen cells from BALB/c J (H-2d) (but not from CBA/J or DBA/2/J) males. Similarly, three out of nine recombinant inbred strains (recombining BALB/c and DBA2 genomes to the homozygous state) possess antiabortive effects like the BALB/c parent. Previous studies showed that BALB/c pretreatment triggers the appearance of suppressor cells in the spleen and of IgG1 anti-H-2d antibodies in the serum of CBA/J females. Studies of these two immunological parameters after CBA/J preimmunization by the different recombinant strains suggest that local intrauterine immunoregulation is the determinant of success or failure of allopregnancy.