Association between extreme autistic traits and intellectual disability: insights from a general population twin study
Association between extreme autistic traits and intellectual disability: insights from a general population twin study
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DOI：
10.1192/bjp.bp.108.060889
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发表时间：
2009-12-01
影响因子：
10.5
通讯作者：
Ronald, A.
中科院分区：
文献类型：
--
作者：
Hoekstra, R. A.;Happe, F.;Ronald, A.
背景自闭症与智力障碍有关。这种关联的强度和起源尚不清楚。目的从社区样本中调查儿童极端自闭症特征与智力障碍之间的关联，并检验这种关联是否可以用遗传因素来解释。方法从7965对7/8岁双胞胎和3687对9岁双胞胎中选择自闭症特征、智商和学业成绩得分在极端5%的儿童。将极端自闭症特征和智力障碍之间的表型关联与全范围分数之间的关联进行比较。使用双变量 DeFries-Fulker 极端分析估计遗传相关性。结果极端自闭症特征与智力障碍有一定相关性；这种关联是由自闭症特征的沟通问题驱动的。虽然这种关联很大程度上是由遗传因素解释的，但自闭症特征和智力障碍之间的遗传相关性很小。结论极端自闭症特征在遗传上基本上与智力障碍无关。
BackgroundAutism is associated with intellectual disability. The strength and origin of this association is unclear.AimsTo investigate the association between extreme autistic traits and intellectual disability in children from a community-based sample and to examine whether the association can be explained by genetic factors.MethodChildren scoring in the extreme 5% on measures of autistic traits, IQ and academic achievement were selected from 7965 7/8-year-old and 3687 9-year-old twin pairs. Phenotypic associations between extreme autistic traits and intellectual disability were compared with associations among the full-range scores. Genetic correlations were estimated using bivariate DeFries-Fulker extremes analyses.ResultsExtreme autistic traits were modestly related to intellectual disability; this association was driven by communication problems characteristic of autism. Although this association was largely explained by genetic factors, the genetic correlation between autistic traits and intellectual disability was only modest.ConclusionsExtreme autistic traits are substantially genetically independent of intellectual disability.