Cardiovascular-specific mortality among multiple myeloma patients: a population-based study.
Cardiovascular-specific mortality among multiple myeloma patients: a population-based study.
复制标题
DOI：
10.1177/20406207221086755
复制
发表时间：
2022
影响因子：
3.4
通讯作者：
Sun C
中科院分区：
文献类型：
--
作者：
Yin X;Fan F;Zhang B;Hu Y;Sun C
近几十年来，多发性骨髓瘤（MM）的生存率大大提高。MM通常在66 - 70岁的中位年龄诊断。MM患者不一定死于原发性癌症，因此心血管健康可能是威胁长期生存的关键因素。本研究旨在探索MM患者的心血管疾病死亡率（CVM）趋势，并将其与一般人群进行比较。总共纳入了来自监测、流行病学和最终结果（SEER）数据库（1975 - 2016）的88，328例MM患者。标准化死亡率（SMR）用于评估CVM风险。MM患者的CVM风险显著高于一般人群（SMR，1.84（95% CI，1.78 - 1.89））。MM患者在诊断后第一年的CVM SMR最高，为2.62（95% CI，2.49 - 2.75），并在随访期间下降。在研究期间，在65 - 74岁（APC，− 1.2%（95%CI，− 1.9%至− 0.4%））和> 75岁（APC，− 1.9%（95%CI，− 2.6%至− 1.2%））诊断的MM患者中，CVM的发生率继续下降，但不年轻。脑血管畸形是75岁以下患者的第二大常见死因。仅在MM病例分析中，男性、黑人、诊断时年龄较大和诊断年份较早是心脏特异性死亡率的不良预后因素。多发性骨髓瘤患者的脑血管畸形风险显著高于一般人群。为了提高生存率，心血管健康应该在诊断时得到关注。
Multiple myeloma (MM) survival has greatly improved in recent decades. MM is usually diagnosed at a median age of 66–70 years. MM patients do not necessarily die from primary cancer, so cardiovascular health may be a key factor threatening long-term survival. This study was designed to explore the cardiovascular disease mortality (CVM) trends in MM patients and compare them with those in the general population. In total, 88,328 MM patients from the Surveillance, Epidemiology, and End Results (SEER) database (1975–2016) were included. Standardized mortality ratios (SMRs) were used to assess CVM risk. The CVM risk was significantly higher in MM patients than in the general population (SMR, 1.84 (95% CI, 1.78–1.89)). MM patients had the highest CVM SMR, at 2.62 (95% CI, 2.49–2.75), in the first year after diagnosis, and it decreased over the follow-up period. Over the study period, the incidence of CVM continued to decrease in MM patients diagnosed at age 65–74 (APC, −1.2% (95% CI, −1.9% to −0.4%)) and ⩾75 years (APC, −1.9% (95% CI, −2.6% to −1.2%)) but not younger. CVM was the second-most common cause of death in patients ⩾75 years. In only MM case analyses, male sex, Black race, older age at diagnosis, and earlier year of diagnosis were poor prognostic factors for heart-specific mortality. The CVM risk in MM patients was significantly higher than that in the general population. To improve survival, cardiovascular health should receive attention upon diagnosis.
登录
查看更多内容
影响因子：
45.3
作者：
Chanan-Khan, Asher;Sonneveld, Pieter;Richardson, Paul G.
通讯作者：
Richardson, Paul G.
影响因子：
20.3
作者：
Mateos, Maria-Victoria;Hernandez, Jose-M.;San Miguel, Jesus-F.
通讯作者：
San Miguel, Jesus-F.
影响因子：
2.7
作者：
Kistler, Kristin D.;Kalman, Jill;Chari, Ajai
通讯作者：
Chari, Ajai
影响因子：
3.2
作者：
Gupta, Ajay;Pandey, Anvita;Sethi, Sumit
通讯作者：
Sethi, Sumit
影响因子：
18.2
作者：
Herrmann, Joerg;Wohlert, Christine;Lerman, Amir
通讯作者：
Lerman, Amir