EPITHELIAL OVARIAN-TUMORS OF BORDERLINE MALIGNANCY - LONG-TERM FOLLOW-UP
EPITHELIAL OVARIAN-TUMORS OF BORDERLINE MALIGNANCY - LONG-TERM FOLLOW-UP
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DOI：
10.1006/gyno.1993.1218
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发表时间：
1993-09-01
影响因子：
4.7
通讯作者：
RICE, LW
中科院分区：
文献类型：
--
作者：
CASEY, AC;BELL, DA;RICE, LW
1970年至1980年间，39名患者在马萨诸塞州总医院接受了低恶性潜能卵巢上皮肿瘤的原发性手术。85%的患者被发现患有I期疾病，15%被发现患有III期疾病。54%的患者为浆液型肿瘤，39%为粘液型肿瘤，其余患者为子宫内膜样或混合细胞型肿瘤。卵巢二次恶性肿瘤和良性肿瘤常与交界性肿瘤合并或随访发现。胃肠道和子宫内膜腺癌是最常见的第二恶性肿瘤，并且经常与浆液组织学的交界性肿瘤相关。39例患者均获得随访（100%）。平均随访时间为11.8年。69%的患者临床无疾病证据，平均随访14.7年，23%死于其他原因，5%死于疾病，3%死于疾病和败血症。所有死于疾病的患者都在首次手术后7.3年内死亡。7例患者接受保守手术，定义为保留卵巢结石组织。7例患者中6例临床无疾病，平均随访14.6年；1例患者死于其他原因。经保守治疗的患者均无复发。
Thirty-nine patients underwent primary surgery for epithelial ovarian tumors of low malignant potential at the Massachusetts General Hospital between 1970 and 1980. Eighty-five percent of patients were found to have Stage I disease and 15% were found to have Stage III disease. Fifty-four percent of patients had a tumor with serous histology, 39% had a tumor with muccinous histology, and the remainder of patients had tumors with an endometrioid or mixed-cell type. Second malignancies and benign ovarian tumors were frequently found concomitantly with the borderline tumors or in follow-up. Gastrointestinal and endometrial adenocarcinomas were the most common second malignancies and were frequently found associated with a borderline tumor of serous histology. Follow-up was available in all 39 patients (100%). Mean time of follow-up was 11.8 years. Sixty-nine percent of patients are clinically without evidence of disease with a mean follow-up of 14.7 years, 23% died of other causes, 5% died of disease, and 3% died with disease and sepsis. All patients dying with disease did so within 7.3 years of their primary surgery. Seven patients underwent conservative surgery, defined as preservation of stone ovarian tissue. Six of 7 patients are clinically free of disease with a mean follow-up of 14.6 years; 1 patient died of other causes. No patients treated conservatively had a recurrence of their disease.