Use of growth hormone, IGF-I, and insulin for anabolic purpose: Pharmacological basis, methods of detection, and adverse effects
Use of growth hormone, IGF-I, and insulin for anabolic purpose: Pharmacological basis, methods of detection, and adverse effects
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DOI：
10.1016/j.mce.2017.06.010
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发表时间：
2018-03-15
影响因子：
4.1
通讯作者：
Garcia, Jose M.
中科院分区：
文献类型：
--
作者：
Anderson, Lindsey J.;Tamayose, Jamie M.;Garcia, Jose M.
具有合成代谢特性的激素，如生长激素（GH）、胰岛素样生长因子-1 （IGF-I）和胰岛素，通常被专业和休闲运动员滥用，以提高身体能力。诸如此类的性能增强药物（ped）也常被休闲运动员用于改善身体美观。尽管缺乏基于人类证据的数据，但在PED使用者中普遍存在由于生理上的激素补充或兴奋剂而增加肌肉质量的感觉。即便如此，运动员仍将继续滥用ped，希望能重现坊间传闻的结果。重要的是要教育公众和潜在的治疗医生使用PED的风险，包括多种药物和物质依赖的危险。对于研究团体来说，解决与PED使用研究相关的共同挑战也很重要，例如PED管理的伦理考虑，PED使用团体自愿提供信息的普遍沉默，以及随着运动员不断试图绕过现有方法，不断需要改进或创造新的检测方法。这篇综述强调了GH、igf - 1和胰岛素的合成代谢机制和暗示数据，以及可用于诊断每种物质滥用及其各自副作用的特定检测方法的截止范围。爱思唯尔爱尔兰有限公司出版。
Hormones with anabolic properties such as growth hormone (GH), insulin-like growth factor-1 (IGF-I), and insulin are commonly abused among professional and recreational athletes to enhance physical ability. Performance enhancing drugs (PEDs) such as these are also commonly used by recreational athletes to improve body aesthetics. The perception of increased muscle mass due to supraphysiologic hormone supplementation, or doping, is widespread among PED users despite a paucity of evidence based data in humans. Even still, athletes will continue to abuse PEDs in hopes of replicating anecdotal results. It is important to educate the general public and potential treating physicians of the risks of PED use, including the dangers of polypharmacy and substance dependence. It will also be important for the research community to address the common challenges associated with studying PED use such as the ethical considerations of PED administration, the general reticence of the PED-using community to volunteer information, and the constant need to improve or create new detection methods as athletes continually attempt to circumvent current methods. This review highlights the anabolic mechanisms and suggestive data implicating GH, IGF-I, and insulin for use as PEDs, the specific detection methods with cutoff ranges that may be utilized to diagnose abuse of each substance, and their respective side effects. Published by Elsevier Ireland Ltd.