Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity
Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity
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DOI：
10.1016/s0264-410x(03)00199-3
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发表时间：
2003-06-01
期刊：
影响因子：
5.5
通讯作者：
Bottazzi, B
中科院分区：
文献类型：
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作者：
Mantovani, A;Garlanda, C;Bottazzi, B
正五聚蛋白3（PTX 3）是第一个被发现的长五聚蛋白。长正五聚蛋白由C-末端正五聚蛋白结构域和不相关的N-末端部分组成，所述C-末端正五聚蛋白结构域与C-反应蛋白（CRP）和血清淀粉样蛋白P（SAP）组分（经典的短正五聚蛋白）具有序列相似性。PTX 3由不同的细胞类型产生，最显著的是内皮细胞、巨噬细胞和树突细胞，响应于初级炎症信号（例如白细胞介素-1（IL-1）、坏死因子（TNF）、脂多糖（LPS））。它结合不同的配体，包括微生物部分，Clq和凋亡细胞。有证据表明，PTX 3在调节对病原体的先天抗性、炎症反应、可能清除自身成分和女性生育力中发挥作用。(C)2003爱思唯尔科技有限公司版权所有。
Pentraxin 3 (PTX3) is the first long pentraxin identified. Long pentraxins consist of a C-terminal pentraxin domain, which has sequence similarity to C-reactive protein (CRP) and serum amyloid P (SAP) component (the classic short pentraxins), and of an unrelated N-terminal portion. PTX3 is made by diverse cell types, most prominently endothelial cells, macrophages and dendritic cells, in response to primary inflammatory signals (e.g. interleukin-1 (IL-1), turnout necrosis factor (TNF), lipopolysaccharide (LPS)). It binds diverse ligands, including microbial moieties, Clq and apoptotic cells. Evidence suggests that PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. (C) 2003 Elsevier Science Ltd. All rights reserved.