Heart rate conditioning in the pigeon immobilized with alpha-bungarotoxin.
Heart rate conditioning in the pigeon immobilized with alpha-bungarotoxin.
复制标题
用α-银环蛇毒素固定的鸽子的心率调节。
DOI：
10.1016/0006-8993(81)91284-1
复制
发表时间：
1981
期刊：
影响因子：
2.9
通讯作者：
Cohen,DH
中科院分区：
文献类型：
--
作者：
Gold,MR;Cohen,DH
Previous in vitro studies6,8,14,37have yielded conflicting results concerning the physiological effects of α-bungarotoxin (α-BTX) at avian autonomic ganglia. In the present study heart rate change was classically conditioned in pigeons immobilized with α-BTX to assess the effects of this agent on autonomic function in the intact animal.When compared with non-immobilized controls, α-BTX had no significant effect on basal heart rate or on the rate of acquisition, magnitude or dynamics of conditioned heart rate change. Furthermore, a significant difference in performance between groups receiving conditioning and sensitization paradigms clearly indicated the establishment of conditioned responding.It is concluded that α-BTX has little or no effect on the cardiac innervation at doses sufficient to block neuromuscular transmission. The irreversible blockade of neuromuscular transmission by α-BTX without the side-effects produced by most other paralytics26makes it an ideal choice as an immobilizing agent in acute preparations.
