Peptidylarginine deiminase 4 and citrullination in health and disease
Peptidylarginine deiminase 4 and citrullination in health and disease
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DOI：
10.1016/j.autrev.2009.06.002
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发表时间：
2010-01-01
影响因子：
13.6
通讯作者：
Migliorini, Paola
中科院分区：
文献类型：
--
作者：
Anzilotti, Consuelo;Pratesi, Federico;Migliorini, Paola
脱亚胺是由一系列钙结合酶催化的，称为肽基精氨酸脱亚胺酶(PADS)。其中，PAD4亚型因其在某些自身免疫性疾病中的作用而得到更广泛的研究。PAD4定位于单核细胞、T和B细胞、中性粒细胞、嗜酸性粒细胞和NK细胞的胞浆中，并可在细胞激活时移向细胞核。PAD4通过组蛋白的瓜氨酸化在基因调控中发挥生理作用。在类风湿关节炎(RA)中，PAD4有助于ACPA特异性底物的产生，本身也是自身抗体的靶标：PAD14基因的等位基因使亚洲人对RA易感，但在高加索人中不是。在多发性硬化症中，在活动性皮损中观察到脑蛋白的广泛缺失，但到目前为止，PAD14基因在多发性硬化症易感性中的作用尚未被描述。(C)2009爱思唯尔B.V.保留所有权利。
Deimination is catalyzed by a family of calcium binding enzymes, called peptidylarginine deiminases (PADs). Among these, the PAD4 isoform has been more extensively studied for its role in some autoimmune diseases. PAD4 is localized in the cytoplasm of monocytes, T and B cells, neutrophils, eosinophils and NK cells and can move to the nucleus upon cell activation.PAD4 plays a physiological role in gene regulation via citrullination of histones.In rheumatoid arthritis (RA), PAD4 contributes to the generation of ACPA specific substrates and is itself a target of autoantibodies: alleles of the PAD14 gene confer susceptibility to RA in Asians but not in Caucasians. In multiple sclerosis, extensive deimination of brain proteins is observed in active lesions, but no role for the PAD14 gene in susceptibility to MS has been so far described. (C) 2009 Elsevier B.V. All rights reserved.