Acute liver failure: a message found under the skin
Acute liver failure: a message found under the skin
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DOI：
10.1136/pgmj.2004.023382
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发表时间：
2005-04-01
影响因子：
5.1
通讯作者：
Strassburg, CP
中科院分区：
文献类型：
--
作者：
Meier, M;Woywodt, A;Strassburg, CP
急性肝衰竭是一种罕见的综合征，进展迅速，死亡率高。其特征是通常在六周内出现昏迷和凝血功能障碍，但也可能在发病后长达六个月发生。病毒性肝炎、特异质药物引起的肝损伤和对乙酰氨基酚摄入是常见的原因。本报告描述了一个35岁的男子谁提出了急性肝功能衰竭后不久，狂饮。重复病史采集显示，患者接受了臀部双硫仑植入物治疗酒精依赖。患者在手术切除后接受最大限度的支持治疗后恢复，但未进行肝移植。这个病例说明，只有仔细的病史调查才能揭示急性肝衰竭有时令人困惑的原因。
Acute liver failure is a rare syndrome with rapid progression and high mortality. It is characterised by the onset of coma and coagulopathy usually within six weeks but can occur up to six months after the onset of illness. Viral hepatitis, idiosyncratic drug induced liver injury, and acetaminophen ingestion are common causes. This report describes the case of a 35 year old man who presented with acute liver failure shortly after binge drinking. Repeated history taking disclosed a gluteal disulfiram implant that the patient had received to treat his alcohol dependence. The patient recovered with maximum supportive care after surgical removal but without liver transplantation. This case illustrates that only meticulous history taking will disclose the sometimes bewildering causes of acute liver failure.