Amino acid sensing and mTOR regulation: inside or out?
Amino acid sensing and mTOR regulation: inside or out?
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DOI：
10.1042/bst0370248
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发表时间：
2009-02
影响因子：
3.9
通讯作者：
Boyd, C. A. Richard
中科院分区：
文献类型：
--
作者：
Goberdhan, Deborah C. I.;Oemundsdottir, Margret H.;Kazi, Shubana;Reynolds, Bruno;Visvalingam, Shivanthy M.;Wilson, Clive;Boyd, C. A. Richard
关键词：
哺乳动物雷帕霉素靶蛋白（mTOR）在决定生长因子、营养物质和氧气水平如何调节细胞内事件中起着关键作用，这些事件对细胞的活力和生长至关重要。这反映在异常mTOR信号对许多主要人类疾病的影响上，并有助于推动研究，以了解TOR本身是如何调节的。虽然氨基酸可以影响TOR信号传导是很清楚的，但这些分子如何被TOR感知仍然存在争议，这可能是因为随着环境条件的变化，细胞使用不同的机制。甚至它们是否在细胞内部或表面起作用的问题也没有得到解决。这篇综述总结了目前的观点，并提出了一些方法，其中一些模型可能会统一，以产生一个氨基酸检测系统，可以适应环境变化。
Mammalian target of rapamycin (mTOR) plays a key role in determining how growth factor, nutrient and oxygen levels modulate intracellular events critical for the viability and growth of the cell. This is reflected in the impact of aberrant mTOR signalling on a number of major human diseases and has helped to drive research to understand how TOR is itself regulated. While it is clear that amino acids can affect TOR signalling, how these molecules are sensed by TOR remains controversial, perhaps because cells use different mechanisms as environmental conditions change. Even the question of whether they have an effect inside the cell or at its surface remains unresolved. This review summarises current ideas and suggests ways in which some of the models proposed might be unified to produce an amino acid detection system that can adapt to environmental change.