Barriers for integrating personalized medicine into clinical practice: A qualitative analysis
Barriers for integrating personalized medicine into clinical practice: A qualitative analysis
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DOI：
10.1002/ajmg.a.35811
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发表时间：
2013-04-01
影响因子：
2
通讯作者：
Marra, Carlo
中科院分区：
文献类型：
--
作者：
Najafzadeh, Mehdi;Davis, Jennifer C.;Marra, Carlo
基于个体遗传信息的个性化药物定制干预可能会改变未来的常规临床实践。然而，从业者计划如何应用遗传信息来为医疗决策提供信息仍不清楚。我们的目的是调查医生对个性化医疗未来作用的看法，并确定影响他们在实践中使用基因检测的决定的因素。我们在加拿大不列颠哥伦比亚省的三个卫生区域（弗雷泽、温哥华沿海和内陆）进行了三个半结构化焦点小组。在焦点小组中，参与者讨论了关于个性化医疗的四个主题：（i）医生的一般理解，（ii）优点和缺点，（iii）未来临床实践中的潜在影响和作用，以及（iv）将个性化医疗纳入临床实践的感知障碍。大约36%（n=9）的医生自我报告说，他们不熟悉个性化医疗的概念。在引入这一概念后，大多数医生（68%，n= 28中的19）有兴趣将个性化医疗纳入他们的实践，前提是他们能够获得必要的知识和工具。与会者大多认为，基因的发展将直接影响他们未来的做法。重点关注的主要问题是医生获得临床指南的机会以及使用基因检测和数据解释的培训机会。尽管个性化医疗可能带来挑战，但总体而言，焦点小组中的医生表示，如果他们能够获得必要的知识和工具，他们对在实践中使用遗传信息有浓厚的兴趣。(c)2013 Wiley Periodicals，Inc.
Personalized medicinetailoring interventions based on individual's genetic informationwill likely change routine clinical practice in the future. Yet, how practitioners plan to apply genetic information to inform medical decision making remains unclear. We aimed to investigate physician's perception about the future role of personalized medicine, and to identify the factors that influence their decision in using genetic testing in their practice. We conducted three semi-structured focus groups in three health regions (Fraser, Vancouver coastal, and Interior) in British Columbia, Canada. In the focus groups, participants discussed four topics on personalized medicine: (i) physicians' general understanding, (ii) advantages and disadvantages, (iii) potential impact and role in future clinical practice, and (iv) perceived barriers to integrating personalized medicine into clinical practice. Approximately 36% (n=9) of physicians self-reported that they were not familiar with the concept of personalized medicine. After introducing the concept, the majority of physicians (68%, n=19 of 28) were interested in incorporating personalized medicine in their practice, provided they have access to the necessary knowledge and tools. Participants mostly believed that genetic developments will directly affect their practice in the future. The key concerns highlighted were physician's access to clinical guidelines and training opportunities for the use of genetic testing and data interpretation. Despite the challenges that personalized medicine can create, in general, physicians in the focus groups expressed strong interest in using genetic information in their practice if they have access to the necessary knowledge and tools. (c) 2013 Wiley Periodicals, Inc.