Maternal PrEP Use in HIV-Uninfected Pregnant Women in South Africa: Role of Stigma in PrEP Initiation, Retention and Adherence.
Maternal PrEP Use in HIV-Uninfected Pregnant Women in South Africa: Role of Stigma in PrEP Initiation, Retention and Adherence.
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DOI：
10.1007/s10461-021-03374-x
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发表时间：
2022-01
影响因子：
4.4
通讯作者：
Joseph Davey D
中科院分区：
文献类型：
--
作者：
Moran A;Mashele N;Mvududu R;Gorbach P;Bekker LG;Coates TJ;Myer L;Joseph Davey D
撒哈拉以南非洲的孕妇感染艾滋病毒的风险很高，需要有效的方法来预防艾滋病毒。在一组接受暴露前预防（PrEP）的孕妇中，我们使用多变量logistic回归评估了内化和预期的病耻感与首次产前检查时PrEP启动、3个月持续治疗和依从性之间的关系。在控制了相关变量后，高内化和预期的PrEP耻辱感与初次产前检查时较低的PrEP护理启动相关（内化耻辱感= 0.06,95% CI = 0.03-0.11，预期耻辱感= 0.55,95% CI = 0.31-1.00）。调整协变量后，伴侣未接受HIV检测或血清状态未知的女性在3个月时保留PrEP的几率是伴侣接受过HIV检测的女性的1.6倍（aOR = 1.60; 95% CI = 1.02-2.52）。PrEP咨询和孕产妇PrEP干预措施必须考虑个人和关系层面的干预措施，以克服预期的PrEP耻辱感和其他PrEP启动和坚持的障碍。在线版本包含补充材料，可在10.1007/s10461-021-03374-x获得。
Pregnant women in sub-Saharan Africa are at high risk of HIV acquisition and require effective methods to prevent HIV. In a cohort of pregnant women offered Pre-exposure prophylaxis (PrEP), we evaluate the relationship between internalized and anticipated stigma and PrEP initiation at first antenatal visit, 3-month continuation and adherence using multivariable logistic regression. High internalized and anticipated PrEP stigma are associated with lower PrEP care initiation at first antenatal visit (aOR internalized stigma = 0.06; 95% CI = 0.03–0.11 and aOR anticipated stigma = 0.55; 95% CI = 0.31–1.00) compared to women with low reported stigma, after controlling for covariates. Women whose partners have not been tested for HIV or whose serostatus remains unknown have 1.6-times odds of PrEP retention at 3-months compared to women whose partners have been tested (aOR = 1.60; 95% CI = 1.02–2.52) after adjusting for covariates. PrEP counseling and maternal PrEP interventions must consider individual- and relational-level interventions to overcome anticipated PrEP stigma and other barriers to PrEP initiation and adherence. The online version contains supplementary material available at 10.1007/s10461-021-03374-x.
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影响因子：
1.7
作者：
Bekker, Linda-Gail;Rebe, Kevin;Eakles, Robyn
通讯作者：
Eakles, Robyn
DOI：
10.7196/samj.8207
发表时间：
2014-12-01
期刊：
SAMJ: South African Medical Journal
影响因子：
--
作者：
Fatti, G;Shaikh, N;Grimwood, A
通讯作者：
Grimwood, A
影响因子：
1.5
作者：
Koss, Catherine A.;Bacchetti, Peter;Gandhi, Monica
通讯作者：
Gandhi, Monica
影响因子：
3.7
作者：
Dinh, Thu-Ha;Delaney, Kevin P.;Shaffer, Nathan
通讯作者：
Shaffer, Nathan
DOI：
10.1056/nejmoa1108524
发表时间：
2012-08-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baeten JM;Donnell D;Ndase P;Mugo NR;Campbell JD;Wangisi J;Tappero JW;Bukusi EA;Cohen CR;Katabira E;Ronald A;Tumwesigye E;Were E;Fife KH;Kiarie J;Farquhar C;John-Stewart G;Kakia A;Odoyo J;Mucunguzi A;Nakku-Joloba E;Twesigye R;Ngure K;Apaka C;Tamooh H;Gabona F;Mujugira A;Panteleeff D;Thomas KK;Kidoguchi L;Krows M;Revall J;Morrison S;Haugen H;Emmanuel-Ogier M;Ondrejcek L;Coombs RW;Frenkel L;Hendrix C;Bumpus NN;Bangsberg D;Haberer JE;Stevens WS;Lingappa JR;Celum C;Partners PrEP Study Team
通讯作者：
Partners PrEP Study Team