Hirsutellone F, a dimer of antitubercular alkaloids from the seed fungus Trichoderma species BCC 7579
Hirsutellone F, a dimer of antitubercular alkaloids from the seed fungus Trichoderma species BCC 7579
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DOI：
10.1021/ol060926x
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发表时间：
2006-06-22
期刊：
影响因子：
5.2
通讯作者：
Tanticharoen, Morakot
中科院分区：
文献类型：
--
作者：
Isaka, Masahiko;Prathumpai, Wai;Tanticharoen, Morakot
Hirsutellone F(7)是一种新型生物碱二聚体，与已知单体hirsutellones a(1)、B(2)、C(3)从木霉BCC 7579中分离得到。7的结构通过光谱分析得到了证实。利用二聚体7进行的仿生化学研究表明，化合物8（171,1′-脱氢毛甾酮B）可能是所有毛甾酮的前体。
Hirsutellone F (7), a novel alkaloid dimer, was isolated together with known monomers, hirsutellones A (1), B (2), and C (3), from the seed fungus Trichoderma sp. BCC 7579. The structure of 7 was elucidated by spectroscopic analysis. Studies on biomimetic chemistry, using the dimer 7, suggested that compound 8 (17,1'-dehydrohirsutellone B) should be the precursor for all hirsutellones.