Pathohistological classification systems in gastric cancer: Diagnostic relevance and prognostic value
Pathohistological classification systems in gastric cancer: Diagnostic relevance and prognostic value
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DOI：
10.3748/wjg.v20.i19.5679
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发表时间：
2014-05-21
影响因子：
4.3
通讯作者：
Moenig, Stefan
中科院分区：
文献类型：
--
作者：
Berlth, Felix;Bollschweiler, Elfriede;Moenig, Stefan
胃癌的诊断存在几种病理组织学分类系统。许多研究探讨了胃癌的病理组织学特征与患者特征、疾病特异性标准和总体预后之间的相关性。哪种分类系统提供的信息最可靠仍有争议，因此，系统的选择可能会在临床常规中有所不同。除了最常见的分类系统，如Lauren和世界卫生组织（WHO）分类外，其他作者还尝试根据显微镜形态学和患者的临床结局对胃癌进行表征和分类。在50多年的胃癌病理组织学特征的系统分类中，没有在诊断和研究中在世界范围内一致使用的唯一分类系统。然而，一些国家的胃癌治疗指南在治疗决策方面参考了劳伦或世卫组织的分类，这强调了可靠的胃癌分类系统的重要性。胃癌研究的最新结果表明，将胃癌的DNA和RNA特征整合到分类系统中以建立预后相关性可能是有用的。现就不同病理组织学分类系统在胃癌诊断中的相关性及预后价值作一综述。(C)2014百世登出版集团股份有限公司All rights reserved.
Several pathohistological classification systems exist for the diagnosis of gastric cancer. Many studies have investigated the correlation between the pathohistological characteristics in gastric cancer and patient characteristics, disease specific criteria and overall outcome. It is still controversial as to which classification system imparts the most reliable information, and therefore, the choice of system may vary in clinical routine. In addition to the most common classification systems, such as the Lauren and the World Health Organization (WHO) classifications, other authors have tried to characterize and classify gastric cancer based on the microscopic morphology and in reference to the clinical outcome of the patients. In more than 50 years of systematic classification of the pathohistological characteristics of gastric cancer, there is no sole classification system that is consistently used worldwide in diagnostics and research. However, several national guidelines for the treatment of gastric cancer refer to the Lauren or the WHO classifications regarding therapeutic decision-making, which underlines the importance of a reliable classification system for gastric cancer. The latest results from gastric cancer studies indicate that it might be useful to integrate DNA-and RNA-based features of gastric cancer into the classification systems to establish prognostic relevance. This article reviews the diagnostic relevance and the prognostic value of different pathohistological classification systems in gastric cancer. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.