Epidemiology and treatment of Cyclospora cayetanensis infection in Peruvian children
Epidemiology and treatment of Cyclospora cayetanensis infection in Peruvian children
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DOI：
10.1093/clinids/24.5.977
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发表时间：
1997-05-01
影响因子：
11.8
通讯作者：
Sterling, CR
中科院分区：
文献类型：
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作者：
Madico, G;McDonald, J;Sterling, CR
从5836名秘鲁儿童的粪便标本中检出卡耶坦环孢子虫63例(1.1%)，用改良的抗酸染色和紫外光下的自体荧光法检测原虫。患病率最高的是2至4岁的儿童，在63名Cayetan感染儿童中有32%(20)有症状，19名感染儿童参加了为期3天的甲氧普林-磺胺甲恶唑(TMP-SMZ；5/25 mg/[kg.d])的双盲安慰剂对照试验。每天对儿童进行大便检查(平均每名儿童检查样本数+/-SE，19+/-4)，TMP-SMZ组卵囊排泄+/-SE的平均持续时间为4.8+/-1.2天，而安慰剂组为12.1+/-6.1天(P
Cyclospora cayetanensis was detected in fecal specimens from 63 (1.1%) of 5,836 Peruvian children studied over 2 years; the protozoan was detected by modified acid-fast staining and autofluorescence under ultraviolet light. The highest prevalence occurred among children between 2 and 4 years of age, Thirty-two percent (20) of the 63 C, cayetanensis-infected children were symptomatic, Nineteen infected children were enrolled in a double-blind, placebo-controlled trial of a 3-day course of trimethoprim-sulfamethoxazole (TMP-SMZ; 5/25 mg/[kg.d]). Children were followed up with daily stool examinations (mean number of samples examined per child +/- SE, 19 +/- 4), The mean duration of oocyst excretion +/- SE was 4.8 +/- 1.2 days for TMP-SMZ recipients compared with 12.1 +/- 6.1 days for placebo recipients (P