Endoplasmic reticulum stress and cancer.
Endoplasmic reticulum stress and cancer.
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DOI：
10.15430/jcp.2014.19.2.75
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发表时间：
2014-06
影响因子：
2.5
通讯作者：
Chae HJ
中科院分区：
文献类型：
--
作者：
Yadav RK;Chae SW;Kim HR;Chae HJ
内质网（ER）是负责多种细胞功能的主要细胞器，包括蛋白质折叠和成熟以及维持细胞内稳态。ER应激被多种因素激活，并触发未折叠蛋白反应（UPR），其恢复稳态或激活细胞死亡。多项研究已经阐明了ER压力与癌症之间的联系，特别是UPR的参与。UPR似乎可以调节肿瘤的矛盾微环境，因此是肿瘤治疗的耐药机制之一。本文综述了不同的UPR参与肿瘤发生和癌症治疗抵抗的活性。
The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular functions including protein folding and maturation and the maintenance of cellular homeostasis. ER stress is activated by a variety of factors and triggers the unfolded protein response (UPR), which restores homeostasis or activates cell death. Multiple studies have clarified the link between ER stress and cancer, and particularly the involvement of the UPR. The UPR seems to adjust the paradoxical microenvironment of cancer and, as such, is one of resistance mechanisms against cancer therapy. This review describes the activity of different UPRs involved in tumorigenesis and resistance to cancer therapy.