Parallel evolution of Pitx1 underlies pelvic reduction in Scottish threespine stickleback (Gasterosteus aculeatus)
Parallel evolution of Pitx1 underlies pelvic reduction in Scottish threespine stickleback (Gasterosteus aculeatus)
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DOI：
10.1093/jhered/esm066
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发表时间：
2007-09-01
影响因子：
3.1
通讯作者：
Peichel, Catherine L.
中科院分区：
文献类型：
--
作者：
Coyle, Susan M.;Huntingford, Felicity A.;Peichel, Catherine L.
对于自然种群中适应性表型变异的遗传和分子机制，或者当类似的适应性表型在独立种群中出现时，是否利用了类似的遗传和分子机制，人们知之甚少。三刺棘鱼（Gasterosteus aculeatus）是研究这些问题的一个很好的模型系统，因为这些鱼表现出大量的适应性表型变异，并且在多个独立的棘鱼种群中也出现了类似的适应性表型。刺鱼平行进化的一个特别引人注目的模式是骨骼盔甲的减少，这在世界各地的许多淡水地区都发生过。研究三刺棘鱼的新基因和基因组工具使鉴定导致其骨骼盔甲不同成分缺失的基因成为可能。先前的研究表明，Pitx1位点的调控突变可能是导致北美和冰岛独立棘鱼种群盆腔结构丧失的原因。在这里，我们表明Pitx1位点也可能是苏格兰三刺棘鱼种群盆腔缩小的基础，它显然是在与北美种群不同的选择制度下进化出盆腔缩小的。
Little is known about the genetic and molecular mechanisms that underlie adaptive phenotypic variation in natural populations or whether similar genetic and molecular mechanisms are utilized when similar adaptive phenotypes arise in independent populations. The threespine stickleback (Gasterosteus aculeatus) is a good model system to investigate these questions because these fish display a large amount of adaptive phenotypic variation, and similar adaptive phenotypes have arisen in multiple, independent stickleback populations. A particularly striking pattern of parallel evolution in sticklebacks is reduction of skeletal armor, which has occurred in numerous freshwater locations around the world. New genetic and genomic tools for the threespine stickleback have made it possible to identify genes that underlie loss of different elements of the skeletal armor. Previous work has shown that regulatory mutations at the Pitx1 locus are likely responsible for loss of the pelvic structures in independent stickleback populations from North America and Iceland. Here we show that the Pitx1 locus is also likely to underlie pelvic reduction in a Scottish population of threespine stickleback, which has apparently evolved pelvic reduction under a different selection regime than the North American populations.