CONFORMATIONS OF IMMUNOGLOBULIN HYPERVARIABLE REGIONS
CONFORMATIONS OF IMMUNOGLOBULIN HYPERVARIABLE REGIONS
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DOI：
10.1038/342877a0
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发表时间：
1989-12-21
期刊：
影响因子：
64.8
通讯作者：
POLJAK, RJ
中科院分区：
文献类型：
--
作者：
CHOTHIA, C;LESK, AM;POLJAK, RJ
在对已知抗体结构和序列的比较研究的基础上，有人认为抗体的六个高变区中至少有五个具有一小部分主链构象，并且所采用的特定构象是由几个关键的保守残基决定的。这些假设现在得到了对各种抗体大多数高变区结构的相当成功的预测的支持，正如通过与随后确定的结构进行比较所揭示的那样。
On the basis of comparative studies of known antibody structures and sequences it has been argued that there is a small repertoire of main-chain conformations for at least five of the six hypervariable regions of antibodies, and that the particular conformation adopted is determined by a few key conserved residues. These hypotheses are now supported by reasonably successful predictions of the structures of most hypervariable regions of various antibodies, as revealed by comparison with their subsequently determined structures.