Microwave-Assisted Bohlmann-Rahtz Synthesis of Highly Substituted 2-Aminonicotinates
Microwave-Assisted Bohlmann-Rahtz Synthesis of Highly Substituted 2-Aminonicotinates
复制标题
微波辅助 Bohlmann-Rahtz 合成高度取代的 2-氨基烟酸酯
作者：
Bagley M
在酸性或碱性条件下，在乙醇中，在150 °C下微波辐射2-乙氧甲酰基乙脒和乙炔基酮1.5小时促进Bohlmann-Rahtz吡啶合成，得到高度取代的2-氨基烟酸乙酯，具有总的区域控制和合理至优异的产率，随后通过固定在酸性树脂上进行纯化。
Microwave irradiation of 2-carbethoxyacetamidine and an ethynyl ketone under acidic or basic conditions in ethanol at 150 °C for 1.5 hours facilitated Bohlmann–Rahtz pyridine synthesis to give highly substituted ethyl 2-aminonicotinates with total regiocontrol and in reasonable to excellent yield, following purification by immobilization upon an acidic resin.