Two-Year Course of Subfoveal Pigment Epithelial Detachment in Eyes with Age-Related Macular Degeneration and Visual Acuity Better than 20/40
Two-Year Course of Subfoveal Pigment Epithelial Detachment in Eyes with Age-Related Macular Degeneration and Visual Acuity Better than 20/40
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DOI：
10.1159/000337251
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发表时间：
2012-01-01
期刊：
影响因子：
2.6
通讯作者：
Yamamoto, Shuichi
中科院分区：
文献类型：
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作者：
Baba, Takayuki;Kitahashi, Masayasu;Yamamoto, Shuichi
目的：探讨年龄相关性黄斑变性(AMD)和最佳矫正视力(BCVA；=20/40)患者黄斑中心凹下色素上皮脱离(PEDS)的发生过程。方法：将35例(37只眼)黄斑下PED患者分为无血管性PED组(n=11)、脉络膜息肉血管病(PCV)组(n=14)和隐匿性脉络膜新生血管(CNV)组(n=12)。根据需要给予玻璃体腔内贝伐单抗或雷尼贝珠单抗。在基线和初次检查后2年测量BCVA、中心凹厚度、PED厚度和病变大小。结果：无血管组BCVA无明显变化，PCV组BCVA由0.06+/-0.11降至0.23+/-0.15logMAR单位，CNV组BCVA由0.12+/-0.12降至0.71+/-0.70logMAR单位。术后2年，3组患者的中心凹厚度和PED厚度无明显差异，PCV组和CNV组的病变明显大于无血管组。结论：在2年的随访中，带血管的PED患者的视力预后比使用抗血管内皮生长因子药物的非血管性PED患者差。版权所有(C)2012 S.Karger AG，巴塞尔
Purpose: To investigate the course of subfoveal pigment epithelial detachments (PEDs) in eyes with age-related macular degeneration (AMD) and best-corrected visual acuity (BCVA) >= 20/40. Methods: Thirty-seven eyes of 35 patients with a subfoveal PED were divided into an avascular PED group (n = 11), a vascularized PED group due to polypoidal choroidal vasculopathy (PCV, n = 14) and an occult choroidal neovascularization (CNV) group (n = 12). Intravitreal bevacizumab or ranibizumab was given as needed. The BCVA, central foveal thickness, PED thickness, and lesion size were measured at baseline and at 2 years after the initial examination. Results: The BCVA did not change significantly in the avascular group, decreased from 0.06 +/- 0.11 to 0.23 +/- 0.15 logMAR units in the PCV group and from 0.12 +/- 0.12 to 0.71 +/- 0.70 logMAR units in the CNV group. At 2 years, the central foveal and PED thicknesses were not significantly different among the 3 groups, and the lesion was significantly larger in the PCV and CNV groups than in the avascular group. Conclusions: The vascularized PED cases had a poorer visual outcome than avascular PEDs with anti-VEGF drugs at the 2-year follow-up. Copyright (C) 2012 S. Karger AG, Basel