Are increased Foxp3+ regulatory T cells responsible for immunosuppression during HTLV-1 infection? Case reports and review of the literature.
Are increased Foxp3+ regulatory T cells responsible for immunosuppression during HTLV-1 infection? Case reports and review of the literature.
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DOI：
10.1136/bcr-2012-006574
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发表时间：
2012-11-27
期刊：
影响因子：
0.9
通讯作者：
Montes, Martin
中科院分区：
文献类型：
--
作者：
Barros, Nicolas;Woll, Fernando;Montes, Martin
人类嗜T淋巴细胞病毒I型（HTLV-1）相关疾病的研究主要集中在炎症和淋巴组织增生性疾病。然而，HTLV-1感染的免疫抑制后果经常被忽视。在寄生虫病和其他热带疾病频发的发展中国家，机会性感染大大增加了疾病负担。调节性T细胞（Tcells）是能够抑制效应子应答的CD 4 T细胞亚群。在HTLV-1感染期间，HTLV-1相关白血病/淋巴瘤（ATLL）以及非白血病表现中的CD 4 + Foxp 3+细胞增加。然而，关于这些细胞的实际调节功能存在争议。在这份报告中，我们提出了两个案件的HTLV-1 ATLL复杂的寄生生物，我们提供了一个简短的回顾文献FoxP 3+调节性T细胞和它们的作用作为一个可能的机制，发生在HTLV-1感染的免疫抑制表现。
Research of human T lymphotropic virus type I (HTLV-1)-associated diseases is mostly focused on inflammatory and lymphoproliferative disorders. However, the immunosuppressive consequences of HTLV-1 infection are frequently ignored. In developing countries where exposure to parasitic and other tropical diseases is frequent, the burden of disease is significantly increased by opportunistic infections. Regulatory T cells (Tregs) are a CD4 T-cell subset capable of suppressing effector responses. During HTLV-1 infection, CD4+Foxp3+ cells are increased in HTLV-1-associated leukaemia/lymphoma (ATLL) as well as in non-leukaemic presentations. However, controversy exists regarding the actual regulatory function of these cells. In this report, we present two cases of HTLV-1 ATLL complicated by parasitic organisms and we provide a brief review of the literature regarding FoxP3+ regulatory T cells and their role as a possible mechanism for the immunosuppressive manifestations that take place during HTLV-1 infection.