Kidney dysfunction in the postoperative period
Kidney dysfunction in the postoperative period
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DOI：
10.1093/bja/aei018
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发表时间：
2005-07-01
影响因子：
9.8
通讯作者：
Sear, JW
中科院分区：
文献类型：
--
作者：
Sear, JW
围手术期急性肾功能衰竭的发生与高发病率和死亡率相关。虽然这种发病率随不同的外科手术和肾功能衰竭的定义而变化，但我们现在更好地了解了潜在问题的病因。然而，提供肾脏保护的成功策略或“补救治疗”策略要么缺乏，要么未经随机临床试验证实，要么没有显着疗效。本综述考虑了肾脏的生理学和药理学;肾功能试验的表征;术后肾功能不全的原因;目前可用于预防和治疗的方法;以及术后肾损害对患者预后的影响。
The development of perioperative acute renal failure is associated with a high incidence of morbidity and mortality. Although this incidence varies with different surgical procedures and with the definition used for renal failure, we now understand better the aetiology of the underlying problem. However, successful strategies to provide renal protection or strategies for 'rescue therapy' are either lacking, unsubstantiated by randomized clinical trials, or show no significant efficacy. The present review considers the physiology and pharmacology of the kidney; the characterization of tests of renal function; the cause of postoperative renal dysfunction; what is presently available for its prevention and treatment; and the effect of postoperative renal impairment on patient outcome.