Pleiotropic quantitative trait loci contribute to population divergence in traits associated with life-history variation in Mimulus guttatus
Pleiotropic quantitative trait loci contribute to population divergence in traits associated with life-history variation in Mimulus guttatus
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DOI：
10.1534/genetics.105.051227
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发表时间：
2006-03-01
期刊：
影响因子：
3.3
通讯作者：
Willis, JH
中科院分区：
文献类型：
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作者：
Hall, MC;Basten, CJ;Willis, JH
进化生物学家试图了解多变量表型分化的遗传基础。我们构建了一个F-2作图群体（N = 539）之间的两个不同的种群Mimulus guttatus。在一个普通的花园实验中，我们测量了20个花，营养和生活史性状的父母和F-1和F-2杂种。我们采用多性状复合区间作图，以确定数量，效果和程度的多效性数量性状位点（QTL）影响分歧的花，营养，和生活史性状。我们检测到16个影响花性状的QTL，7个影响营养性状，5个影响选定的花，营养和生活史性状。花和营养性状显然是多基因的。我们检测到了一些主效QTL，其余QTL均为小效QTL。大多数检测到的QTL是多效性的，这意味着这些一年生和多年生种群之间的进化转移受到限制。我们还比较了遗传结构控制花性状分歧内（我们的种内研究）和物种之间，在以前发表的分析M。guttatus和M.鼻骨。我们的16个花QTL的11个图在种间图谱的基础上共享，共线标记，这意味着可能有一个共享的遗传基础，花分歧内和种间的Mimulus的大致相同的位置。
Evolutionary biologists seek to understand the genetic basis for multivariate phenotypic divergence. We constructed an F-2 mapping population (N = 539) between two distinct populations of Mimulus guttatus. We measured 20 floral, vegetative, and life-history characters on parents and F-1 and F-2 hybrids in a common garden experiment. We employed multitrait composite interval mapping to determine the number, effect, and degree of pleiotropy quantitative trait loci (QTL) affecting divergence in floral, vegetative, and life-history characters. We detected 16 QTL affecting floral traits; 7 affecting Vegetative traits: and 5 affecting selected floral, vegetative,and life-history traits. Floral and vegetative traits are clearly polygenic. We detected a few major QTL, with all remaining QTL of small effect. Most detected QTL are pleiotropic, implying that the evolutionary shift between these annual and perennial populations is constrained. We also compared the genetic architecture controlling floral trait divergence both within (our intraspecific study) and between species, on the basis of a previously published analysis of M. guttatus and M. nasutus. Eleven of our 16 floral QTL map to approximately the same location in the interspecific map based on shared, collinear markers, implying that there may be a shared genetic basis for floral divergence within and among species of Mimulus.