rPer1 and rPer2 induction during phases of the circadian cycle critical for light resetting of the circadian clock
rPer1 and rPer2 induction during phases of the circadian cycle critical for light resetting of the circadian clock
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DOI：
10.1016/j.brainres.2009.06.051
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发表时间：
2009-09-15
期刊：
影响因子：
2.9
通讯作者：
Shigeyoshi, Yasufumi
中科院分区：
文献类型：
--
作者：
Nagano, Mamoru;Adachi, Akihito;Shigeyoshi, Yasufumi
生物钟的光重置是昼夜节律系统的基本特征之一，并允许生物体适应特定的环境。夜间光照诱导Per1和Per2基因，导致哺乳动物昼夜节律中心视交叉上核（SCN）的昼夜节律钟重置。在我们目前的研究中，我们研究了光是否差异诱导大鼠Per1（rPer1）和Per2（rPer2）基因，使他们的生物钟重置。在一个24小时的LD周期（12小时的光：12小时黑暗），这是短于正常的自由运行期间的大鼠，Per1单独表现出强烈的诱导在腹外侧区的SCN（VLSCN）在早期的一天。相比之下，在25小时LD循环（12.5小时光照：12.5小时黑暗），这是比这些动物的自由运行期长，单独的rPer2强烈诱导VLSCN中，在光相结束时和早期黑暗期间。因此，我们目前的发现表明Per1和Per2对于LD循环的每日夹带是不同调节的。(C)2009爱思唯尔有限公司版权所有。
Photic resetting of a biological clock is one of the fundamental characteristics of circadian systems and allows living organisms to adjust to a particular environment. Nocturnal light induces the Per1 and Per2 genes, which leads to a resetting of the circadian clock in the suprachiasmatic nucleus (SCN), the mammalian circadian center. In our present study, we investigated whether light differentially induces the rat Per1 (rPer1) and Per2 (rPer2) genes to enable resetting of their circadian clocks. In a 24-hour LD cycle (12 h light:12 h dark), which is shorter than the normal free-running period for rats, Per1 alone showed strong induction in the ventrolateral region of the SCN (VLSCN) during the early day. In contrast, in a 2S hour LD cycle (12.5 h light:12.5 h dark), which is longer than the free running period for these animals, rPer2 alone was strongly induced in the VLSCN, at the end of the light phase and during the early dark periods. our current findings therefore suggest that Per1 and Per2 are differentially regulated for daily entrainment to the LD cycle. (C) 2009 Elsevier B.V. All rights reserved.