Cohort profile: prescriptions dispensed in the community linked to the national cancer registry in England
Cohort profile: prescriptions dispensed in the community linked to the national cancer registry in England
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DOI：
10.1136/bmjopen-2017-020980
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发表时间：
2018-09-01
期刊：
影响因子：
2.9
通讯作者：
Rashbass, Jem
中科院分区：
文献类型：
--
作者：
Henson, Katherine E.;Brock, Rachael;Rashbass, Jem
目的建立关联处方癌症登记数据资源，以扩展我们对癌症患者通过二级护理进入社区的途径的理解，最终改善患者的治疗效果。参与者关联处方癌症登记数据资源目前可用于2015年4月至7月，适用于英格兰所有诊断为癌症的患者，并在该时间范围内分配处方。处方数据由英国国家卫生服务（NHS）处方服务部门收集，癌症登记数据由英国公共卫生部门处理。所有数据都是常规医疗保健数据，用于次要目的，使用患者的NHS号码和出生日期的简化版本进行链接。癌症登记处收集关于诊断和治疗的癌症类型的详细人口统计学和临床信息。处方数据包含基本的人口统计信息、处方的地理度量、药物信息（数量，强度和介绍），药物的成本和分发的处方提交给NHS商业服务管理局的日期。迄今为止的研究结果包括一项关于癌症患者在社区中的临终处方的研究，对重复处方的调查，以获得癌症患者先前发病状况的测量结果，以及围绕癌症诊断日期的处方活动研究。未来计划此英语链接的资源可用于诊断途径，健康结果和不平等的癌症流行病学研究;建立初级保健合并症指数和治疗指南一致性研究，特别是激素治疗，作为乳腺癌和前列腺癌的主要治疗方式，多年来主要在社区环境中提供。
Purpose The linked prescriptions cancer registry data resource was set up to extend our understanding of the pathway for patients with cancer past secondary care into the community, to ultimately improve patient outcomes.Participants The linked prescriptions cancer registry data resource is currently available for April to July 2015, for all patients diagnosed with cancer in England with a dispensed prescription in that time frame. The dispensed prescriptions data are collected by National Health Service (NHS) Prescription Services, and the cancer registry data are processed by Public Health England. All data are routine healthcare data, used for secondary purposes, linked using a pseudonymised version of the patient's NHS number and date of birth. Detailed demographic and clinical information on the type of cancer diagnosed and treatment is collected by the cancer registry. The dispensed prescriptions data contain basic demographic information, geography measures of the dispensed prescription, drug information (quantity, strength and presentation), cost of the drug and the date that the dispensed prescription was submitted to NHS Business Services Authority.Findings to date Findings include a study of end of life prescribing in the community among patients with cancer, an investigation of repeat prescriptions to derive measures of prior morbidity status in patients with cancer and studies of prescription activity surrounding the date of cancer diagnosis.Future plans This English linked resource could be used for cancer epidemiological studies of diagnostic pathways, health outcomes and inequalities; to establish primary care comorbidity indices and for guideline concordance studies of treatment, particularly hormonal therapy, as a major treatment modality for breast and prostate cancer which has been largely delivered in the community setting for a number of years.