Innate and procured immunity inside the digestive tract of the medicinal leech.
Innate and procured immunity inside the digestive tract of the medicinal leech.
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发表时间：
2011-08
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通讯作者：
Adam C. Silver;Joerg Graf
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作者：
Adam C. Silver;Joerg Graf
特别是当与独特的生物适应相结合时，无脊椎动物提供了对先天免疫的重要见解，因为免疫反应不会因脊椎动物进化的适应性免疫而复杂化。一个这样的例子是药用水蛭的消化道，水蛭在两个方面是不寻常的，它包含一个简单的微生物群落，它储存了大量的脊椎动物血液几个月。在这篇综述中，我们将讨论水蛭的先天免疫的各个方面，并从摄入的血液，我们称之为采购免疫，以区分它从水蛭基因组编码的免疫。
Especially when combined with unique biological adaptations, invertebrate animals provide important insights into innate immunity because the immune response is not complicated by adaptive immunity that vertebrates evolved. One such example is the digestive tract of the medicinal leech, Hirudo verbana, which is unusual in two aspects, it contains a simple microbial community and it stores large amounts of vertebrate blood for a several months. In this review we will discuss aspects of the innate immunity of the leech and from the ingested blood that we term procured immunity to differentiate it from the immunity encoded by the leech genome.