Hepatic bilirubin glucuronidation in Gilbert's syndrome.
Hepatic bilirubin glucuronidation in Gilbert's syndrome.
复制标题
吉尔伯特综合征中的肝胆红素葡萄糖醛酸化。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
N. Carpio
中科院分区：
文献类型：
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作者：
B. Felsher;J. R. Craig;N. Carpio
摘要 对正常受试者、吉尔伯特综合征患者以及急性病毒性肝炎患者的肝活检标本进行了肝胆红素尿苷二磷酸 - 葡萄糖醛酸转移酶（UDPG - T）和β - 葡萄糖醛酸苷酶的检测。在吉尔伯特综合征组中，UDPG - T均降低，与血清胆红素浓度无关，不受热量摄入的急性变化影响，苯巴比妥给药也未使其显著改变。在肝炎组中，UDPG - T正常，且经苯巴比妥治疗后显著升高（p
Abstract Hepatic bilirubin uridine diphosphate-glucuronyl transferase (UDPG-T) and β-glucuronidase were assayed in liver biopsies from normal subjects, patients with Gilbert's syndrome, and patients with acute viral hepatitis. In the Gilbert's syndrome group UDPG-T was uniformly reduced, unrelated to the serum bilirubin concentration, unaffected by acute changes in caloric intake, and not significantly altered by phenobarbital administration. In the hepatitis group, UDPG-T was normal and significantly increased by phenobarbital (p