A COMPARISON OF OPTIMAL AND SUBOPTIMAL RNA SECONDARY STRUCTURES PREDICTED BY FREE-ENERGY MINIMIZATION WITH STRUCTURES DETERMINED BY PHYLOGENETIC COMPARISON
A COMPARISON OF OPTIMAL AND SUBOPTIMAL RNA SECONDARY STRUCTURES PREDICTED BY FREE-ENERGY MINIMIZATION WITH STRUCTURES DETERMINED BY PHYLOGENETIC COMPARISON
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DOI：
10.1093/nar/19.10.2707
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发表时间：
1991-05-25
影响因子：
14.9
通讯作者：
TURNER, DH
中科院分区：
文献类型：
--
作者：
ZUKER, M;JAEGER, JA;TURNER, DH
本文介绍了最新版本的RNA折叠算法，预测自由能最小化的基础上的最佳和次优的解决方案。将从比较序列分析推导出的具有已知结构的许多RNA折叠以测试程序性能。对每个分子得到的解组进行分析，以确定有多少已知螺旋出现在最优解和最佳次优解中。在大多数情况下，发现约80%正确的结构，其自由能在预测的最低自由能结构的2%内。
This article describes the latest version of an RNA folding algorithm that predicts both optimal and suboptimal solutions based on free energy minimization. A number of RNA's with known structures deduced from comparative sequence analysis are folded to test program performance. The group of solutions obtained for each molecule is analysed to determine how many of the known helixes occur in the optimal solution and in the best suboptimal solution. In most cases, a structure about 80% correct is found with a free energy within 2% of the predicted lowest free energy structure.