Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs.
Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs.
复制标题
DOI：
10.3390/biom5042207
复制
发表时间：
2015-09-24
期刊：
影响因子：
5.5
通讯作者：
Gerber AP
中科院分区：
文献类型：
--
作者：
Iadevaia V;Gerber AP
基因表达的转录后控制由RNA结合蛋白（RBP）和小的非编码RNA（例如，microRNA）结合其mRNA靶中的不同元件。在这里，我们回顾了最近的例子描述的协同和/或拮抗作用介导的RBP和miRNA，以确定在哺乳动物细胞中的mRNA的定位，稳定性和翻译。从这些研究中，越来越明显的是，RNA-蛋白质复合物的动态重排可能在人类癌症、突触可塑性和细胞分化中具有深远的意义。
Post-transcriptional control of gene expression is mediated by RNA-binding proteins (RBPs) and small non-coding RNAs (e.g., microRNAs) that bind to distinct elements in their mRNA targets. Here, we review recent examples describing the synergistic and/or antagonistic effects mediated by RBPs and miRNAs to determine the localisation, stability and translation of mRNAs in mammalian cells. From these studies, it is becoming increasingly apparent that dynamic rearrangements of RNA-protein complexes could have profound implications in human cancer, in synaptic plasticity, and in cellular differentiation.