Transdifferentiation of corneal epithelium: evidence for a linkage between the segregation of epidermal stem cells and the induction of hair follicles during embryogenesis
Transdifferentiation of corneal epithelium: evidence for a linkage between the segregation of epidermal stem cells and the induction of hair follicles during embryogenesis
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DOI：
10.1387/ijdb.15272385
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发表时间：
2004-01-01
影响因子：
0.7
通讯作者：
Dhouailly, D
中科院分区：
文献类型：
--
作者：
Pearton, DJ;Ferraris, C;Dhouailly, D
角膜上皮转分化为毛发表皮提供了一个特别有用的系统，用于研究瞬时扩增（TA）细胞能够激活不同的遗传程序，以响应其成纤维细胞环境的变化，以及遵循不同的步骤，从诱导的干细胞重建表皮的可能性。角膜干细胞和TA细胞存在于不同的位置--干细胞位于周边、利姆布斯中，TA细胞位于更中心的位置。此外，TA细胞已经表达分化中的角膜型角蛋白对K3/K12，而角膜缘角化细胞表达基底角蛋白对K5/K14。相反，基底上表皮角质形成细胞表达角蛋白对K1-2/1，
Corneal epithelium transdifferentiation into a hair-bearing epidermis provides a particularly useful system for studying the possibility that transient amplifying (TA) cells are able to activate different genetic programs in response to a change in their fibroblast environment, as well as to follow the different steps of rebuilding an epidermis from induced stem cells. Corneal stem and TA cells are found in different locations - stem cells at the periphery, in the limbus, and TA cells more central. Moreover, the TA cells already express the differentiating corneal-type keratin pair K3/K12, whereas the limbal keratinocytes express the basal keratin pair K5/K14. In contrast, suprabasal epidermal keratinocytes express keratin pair K1-2/1