Predominant expression of rTERTb, an inactive TERT variant, in the adult rat brain
Predominant expression of rTERTb, an inactive TERT variant, in the adult rat brain
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DOI：
10.2174/092986606774502108
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发表时间：
2006-01-01
影响因子：
1.6
通讯作者：
Hirabayashi, T
中科院分区：
文献类型：
--
作者：
Kaneko, R;Esumi, S;Hirabayashi, T
鉴定了大鼠TERT的全长和4个选择性剪接变异体mRNA转录本。其中一个变异体rTERTb主要在大脑发育过程中表达，与端粒酶活性的下降相一致。RTERTb基因编码一种无活性的截短蛋白。TERT的选择性剪接在大脑发育过程中可能很重要。
The full-length and four alternatively spliced variant mRNA transcripts of rat TERT were identified. One of the variant, rTERTb, was predominantly expressed during brain development in accordance with the decrease in telomerase activity. The rTERTb mRNA encoded an inactive truncated protein. Alternative splicing of TERT may be important during brain development.