IMMUNOSUPPRESSIVE ACTIONS OF 1,25-DIHYDROXYVITAMIN D-3 - PREFERENTIAL INHIBITION OF TH-1 FUNCTIONS
IMMUNOSUPPRESSIVE ACTIONS OF 1,25-DIHYDROXYVITAMIN D-3 - PREFERENTIAL INHIBITION OF TH-1 FUNCTIONS
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DOI：
10.1093/jn/125.suppl_6.1704s
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发表时间：
1995-06-01
影响因子：
4.2
通讯作者：
SPIEGELBERG, HL
中科院分区：
文献类型：
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作者：
LEMIRE, JM;ARCHER, DC;SPIEGELBERG, HL
1,25-二羟基维生素D-3 [1,25-(OH)(2)-D-3]是一种免疫抑制激素。本综述主要研究1,25-(OH)(2)-D-3和类似物1,25-二羟基-16烯-维生素D-3 [1,25-(OH)(2)-16烯-D-3]在体外和体内对人体具有独特功能特征的1型（Th-1）或2型（Th-2） T辅助亚群的影响。Th分泌干扰素（ifn - γ）、白细胞介素（IL-2），诱导B细胞产生免疫球蛋白IgG(2a)； Th-2分泌IL-4、IL-10，诱导B细胞产生IgG(1)和IgE。甾醇抑制IL-12的分泌，IL-12是单核细胞和B细胞产生的细胞因子，导致Th的激活和分化。此外，1,25-(OH)(2)- d -3直接抑制Th-2无性系分泌ifn - γ，而对Th-2无性系分泌IL-4影响不大。类似物1,25-(OH)(2)- 16烯- d -3在抑制ifn - γ分泌方面的效力是1,25-(OH)(2)- d -3的100倍，但对IL-4的分泌也几乎没有影响。在小鼠体内给药时，甾醇可防止自发性和诱导性自身免疫性疾病的诱导，并抑制Th，诱导IgG（2a）反应。维生素D-3化合物的这些作用表明，它可能在th -1介导的临床情况（如自身免疫和移植）中具有潜在的治疗应用。
1,25-Dihydroxyvitamin D-3 [1,25-(OH)(2)-D-3] is known to be an immunosuppressive hormone. This review primarily deals with in vitro and in vivo effects of 1,25-(OH)(2)-D-3 and analogue, 1,25-dihydroxy-16ene-vitamin D-3 [1,25-(OH)(2)-16ene-D-3], on T helper subsets type 1 (Th-1) or type 2 (Th-2) that have distinctive functional characteristics in humans. Th, secrete interferon (IFN-gamma), interleukin (IL-2) and induce B cells to produce immunoglobulin IgG(2a) while Th-2 secrete IL-4, IL-10 end induce the production of IgG(1) and IgE by B cells. The sterol inhibits the secretion of IL-12, a cytokine produced by monocytes and B cells, which leads to the activation and differentiation of Th,. In addition, 1,25-(OH)(2)-D-3 directly inhibits IFN-gamma secretion by Th, clones while it has little effect on IL-4 secretion by Th-2 clones. The analogue, 1,25-(OH)(2)-16ene-D-3, is 100-fold more potent than 1,25-(OH)(2)-D-3 in inhibiting IFN-gamma secretion but also has little effect on IL-4 secretion. In mice, when given in vivo, the sterol prevents the induction of spontaneous and induced autoimmune diseases and inhibits Th, induce IgG(2a) responses. These actions of the vitamin D-3 compounds suggest that it may have potential therapeutic applications in Th-1-mediated clinical situations such as autoimmunity and transplantation.