Doppler derived quantitative flow estimate in coronary artery bypass graft: A computational multiscale model for the evaluation of the current clinical procedure
Doppler derived quantitative flow estimate in coronary artery bypass graft: A computational multiscale model for the evaluation of the current clinical procedure
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DOI：
10.1016/j.medengphy.2007.09.004
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发表时间：
2008-09-01
影响因子：
2.2
通讯作者：
Redaelli, Alberto
中科院分区：
文献类型：
--
作者：
Ponzini, Raffaele;Lemma, Massimo;Redaelli, Alberto
为了研究临床实践中使用血管内多普勒导丝仪器估计流速的所谓平均速度/血管面积公式的可靠性，使用多尺度计算模型对 Y 形冠状动脉旁路移植术 (CABG) 模型中的血流剖面进行详细预测。为此，根据临床患者的数据建立了三个 CABG 模型，并用于评估和比较每个模型中计算的流速和根据抛物线速度分布假设估计的流速。在所有移植模型的每个分支中都发现流速的精确值和估计值之间存在一致的差异。在这项研究中，我们表明，流量估计中的这种差异与沃默斯利关于非定常流动条件下空间速度剖面的理论是一致的。特别是这项工作证明，通过使用 Ponzini 等人最近提出的估计公式可以减少流量估计的误差。 [Ponzini R、Vergara C、Redaelli A、Veneziani A。血液动力学测量中基于 CFD 的可靠流速估计。 Ultrasound Med Biol 2006;32(10):1545-55]，解释了血液的不稳定性质，适用于临床实践而无需诉诸进一步的测量。 (C) 2007 年 IPEM。由爱思唯尔有限公司出版。保留所有权利。
In order to investigate the reliability of the so called mean velocity/vessel area formula adopted in clinical practice for the estimation of the flow rate using an intravascular Doppler guide wire instrumentation, a multiscale computational model was used to give detailed predictions on flow profiles within Y-shaped coronary artery bypass graft (CABG) models. At this purpose three CABG models were built from clinical patient's data and used to evaluate and compare, in each model, the computed flow rate and the flow rate estimated according to the assumption of parabolic velocity profile.A consistent difference between the exact and the estimated value of the flow rate was found in every branch of all the graft models. In this study we showed that this discrepancy in the flow rate estimation is coherent to the theory of Womersley regarding spatial velocity profiles in unsteady flow conditions. In particular this work put in evidence that the error in flow rate estimation can be reduced by using the estimation formula recently proposed by Ponzini et al. [Ponzini R, Vergara C, Redaelli A, Veneziani A. Reliable CFD-based estimation of flow rate in haemodynamics measures. Ultrasound Med Biol 2006;32(10):1545-55], accounting for the unsteady nature of blood, applicable in the clinical practice without resorting to further measurements. (C) 2007 IPEM. Published by Elsevier Ltd. All rights reserved.