Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents
Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents
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DOI：
10.1016/j.biomaterials.2010.04.056
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发表时间：
2010-09-01
期刊：
影响因子：
14
通讯作者：
Grull, Holger
中科院分区：
文献类型：
--
作者：
de Vries, Anke;Custers, Erica;Grull, Holger
本研究的目的是开发不透射线的碘化乳剂，用作 CT 血池造影剂。基于 2,3,5-三碘苯甲酸酯部分合成了三种疏水性碘化油，并使用磷脂或两亲性聚合物（即 Pluronic F68 和聚（丁二烯）-b-聚（乙二醇）（PBD-PEO））作为乳化剂配制成乳液。研究了所有稳定乳液的尺寸、稳定性和细胞活力。随后在小鼠体内测试了用脂质或 PBD-PEO 稳定的三种乳液作为 CT 血池造影剂。虽然脂质稳定乳液在体内不稳定，但聚合物稳定乳液在体内表现良好。在血液中，静脉注射 520 mg l/kg 后直接测量到 220 Hounsfield 单位 (HU) 的对比度增强。 PBD-PEO 稳定乳液的血液循环半衰期约为 3 小时，未观察到明显的体内毒性。这些结果表明上述乳液在对比增强 CT 成像中用作血池剂的潜力。 (C) 2010 Elsevier Ltd. 保留所有权利。
The objective of this study was to develop radiopaque iodinated emulsions for use as CT blood pool contrast agents. Three hydrophobic iodinated oils were synthesized based on the 2,3,5-triiodobenzoate moiety and formulated into emulsions using either phospholipids or amphiphilic polymers, i.e. Pluronic F68 and poly(butadiene)-b-poly(ethylene glycol) (PBD-PEO), as emulsifiers. The size, stability and cell viability was investigated for all stabilized emulsions. Three emulsions stabilized with either lipids or PBD-PEO were subsequently tested in vivo as a CT blood pool contrast agent in mice. While the lipid-stabilized emulsions turned out unstable in vivo, polymer-stabilized emulsions performed well in vivo. In blood, a contrast enhancement of 220 Hounsfield Units (HU) was measured directly after intravenous administration of 520 mg l/kg. The blood circulation half-life of a PBD-PEO stabilized emulsion was approximately 3 h and no noticeable in vivo toxicity was observed. These results show the potential of above emulsions for use as blood pool agents in contrast enhanced CT imaging. (C) 2010 Elsevier Ltd. All rights reserved.