Amphetamine-induced displacement of [18F] fallypride in striatum and extrastriatal regions in humans
Amphetamine-induced displacement of [18F] fallypride in striatum and extrastriatal regions in humans
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DOI：
10.1038/sj.npp.1300916
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发表时间：
2006-05-01
影响因子：
7.6
通讯作者：
Kessler, R
中科院分区：
文献类型：
--
作者：
Riccardi, P;Li, R;Kessler, R
本研究探讨了D-苯丙胺（D-AMPH）诱导的[F-18] fallypride在纹状体和纹状体外区域的位移，以及这些位移与认知，情感和感觉寻求行为的相关性。总共有14名正常受试者，6名女性和8名男性（年龄21-32岁，平均年龄25.9岁），在口服0.43 mg/kg D-AMPH之前和之后3 h接受了[F-18] fallypride的正电子发射断层扫描（PET）。多巴胺（DA）D-2受体密度的水平用Lammerstma的参考区域方法计算。计算尾状核、壳核、腹侧纹状体、内侧丘脑、杏仁核、黑质和颞叶皮质的纹状体和纹状体外区域的位移百分比。计算了认知、情感和感觉寻求变化与D-AMPH诱导的DA释放的参数图像的相关性。在尾状核、壳核、腹侧纹状体、黑质和颞叶皮质中观察到显著位移，杏仁核中的趋势水平变化。最大的位移出现在纹状体分区-尾状核5.6%，壳核11.2%，腹侧纹状体7.2%，黑质6.6%。杏仁核（4.4%）、颞叶皮质（3.7%）和丘脑（2.8%）出现较小程度的减少。观察到区域DA释放与认知和感觉寻求行为的显著相关性。目前的研究表明，使用口服D-AMPH（0.43 mg/kg）的[F-18] fallypride PET研究可用于研究人类纹状体和纹状体外区域中D-AMPH诱导的DA释放，以及它们与认知和感觉寻求行为的关系。
This study examined D-amphetamine (D-AMPH)-induced displacements of [F-18] fallypride in striatal and extrastriatal regions and the correlations of these displacements with cognition, affect, and sensation-seeking behavior. In all, 14 normal subjects, six females and eight males (ages 21-32, mean age 25.9 years), underwent positron emission tomography (PET) with [F-18] fallypride before and 3 h after a 0.43 mg/kg oral dose of D-AMPH. Levels of dopamine (DA) D-2 receptor density were calculated with the reference region method of Lammerstma. Percent displacements in striatal and extrastriatal regions were calculated for the caudate, putamen, ventral striatum, medial thalamus, amygdala, substantia nigra, and temporal cortex. Correlations of changes in cognition, affect, and sensation seeking with parametric images of D-AMPH- induced DA release were computed. Significant displacements were seen in the caudate, putamen, ventral striatum substantia nigra, and temporal cortex with a trend level change in the amygdala. Greatest displacements were seen in striatal subdivisions - 5.6% in caudate, 11.2% in putamen, 7.2% in ventral striatum, and 6.6% in substantia nigra. Lesser decrements were seen in amygdala - 4.4%, temporal cortex - 3.7%, and thalamus - 2.8%. Significant clusters of correlations of regional DA release with cognition and sensation-seeking behavior were observed. The current study demonstrates that [F-18] fallypride PET studies using oral D-AMPH (0.43 mg/kg) can be used to study D-AMPH- induced DA release in the striatal and extrastriatal regions in humans, and their relationship with cognition and sensation-seeking behavior.