Electrostatic zipper motif for DNA aggregation
Electrostatic zipper motif for DNA aggregation
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DOI：
10.1103/physrevlett.82.4138
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发表时间：
1999-05-17
影响因子：
8.6
通讯作者：
Leikin, S
中科院分区：
文献类型：
--
作者：
Kornyshev, AA;Leikin, S
从螺旋分子之间静电相互作用的理论，占不同的电荷分布模式的DNA凝聚的counterweight特异性是合理的。由于螺旋槽中的离子结合而引起的轴向电荷分离允许相反电荷沿着DNA-DNA接触紧密接近，并形成将分子“拉”在一起的静电“拉链”。理论预测与实验数据一致。
Counterion specificity of DNA condensation is rationalized from a theory of electrostatic interaction between helical molecules that accounts for different charge distribution patterns. an axial charge separation due to ion binding in helical grooves allows close approach of opposite charges along the DNA-DNA contact and forms an electrostatic "zipper" that "fastens" the molecules together. Predictions of the theory are in agreement with experimental data.