TRICHINELLA-SPIRALIS - VASCULAR RECIRCULATION AND ORGAN RETENTION OF NEWBORN LARVAE IN RATS
TRICHINELLA-SPIRALIS - VASCULAR RECIRCULATION AND ORGAN RETENTION OF NEWBORN LARVAE IN RATS
复制标题
DOI：
10.1016/0014-4894(86)90052-4
复制
发表时间：
1986-12-01
影响因子：
2.1
通讯作者：
BELL, RG
中科院分区：
文献类型：
--
作者：
WANG, CH;BELL, RG
本文研究了旋毛虫新生幼虫在近交系AO大鼠体内的再循环。在离体培养的条件下，收集新生幼虫。经尾静脉或肝门静脉向大鼠体内注射2或24小时的蠕虫。从股静脉，肝门静脉，腹主动脉的血液样品收集间隔从1分钟至24小时后幼虫注射。两个年龄段的新生幼虫（24小时或2小时龄）在股静脉血液中持续时间≤ 10小时。注射后5小时，但在注射后24小时门静脉血中不能检测到它们。将幼虫注射到尾静脉或门静脉中不影响幼虫循环的模式，尽管注射到门静脉中后新生幼虫的出现时间延迟1-5分钟。新生幼虫尾静脉注射后24小时（偶尔48小时），胸导管淋巴中新生幼虫的外观明显可见经肩胛骨迁移通过组织并返回循环。在自然原发感染的过程中，没有证据表明诱捕幼虫在肠系膜淋巴结中，可以发现，尽管直接幼虫迁移通过这个器官。注射的新生幼虫保留在肺中，静脉注射后24小时可回收少量。我们的结论是，新生幼虫的比例再循环内的脉管系统几个小时：一个较小的人口extravastates，但可以重新进入循环系统，通过atmosphatics。此外，一些新生幼虫在进入血液后24小时内在器官中发现，毛细血管丰富。
The recirculation of Trichinella spiralis newborn larvae was studied in inbred AO rats. Newborn larvae collected after in vitro incubation of adult T. spiralis worms for 2 or 24 hr were injected into rats through the tail vein or hepatic portal vein. Blood samples from the femoral vein, hepatic portal vein, and abdominal aorta were collected at intervals from 1 min to 24 hr after larval injection. Newborn larvae of both ages (24 hr or 2 hr old) persisted in femoral vein blood for .ltoreq. 5 hr after injection, but they could not be detected in portal vein blood by 24 hr after injection. The injection of larvae into a tail vein or the portal vein did not influence the pattern of larval circulation, although there was a 1-5 min delay in new-born larval appearance time after injection into the portal vein. Transcapillary migration through tissue and back to the circulation was evident in the appearance of newborn larvae in the thoracic duct lymph up to 24 (occasionally 48) hr after tail vein injection of newborn larvae. During the course of a natural primary infection, no evidence for trapping of larvae in the mesenteric lymph node could be found despite direct larval migration through this organ. Injected newborn larvae were retained in the lungs, and small numbers could be recovered 24 hr after intravenous injection. We conclude that a proportion of newborn larvae recirculates within the vasculature for several hours: a smaller population extravastates but can reenter the circulatory system via the lymphatics. Furthermore, some newborn larvae are found in organs, rich in capillaries up to 24 hr after their entry into the blood.