Relation of left ventricular hypertrophy to inflammation and albuminuria in adults with type 2 diabetes - The Strong Heart Study
Relation of left ventricular hypertrophy to inflammation and albuminuria in adults with type 2 diabetes - The Strong Heart Study
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DOI：
10.2337/diacare.26.10.2764
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发表时间：
2003-10-01
期刊：
影响因子：
16.2
通讯作者：
Devereux, RB
中科院分区：
文献类型：
--
作者：
Palmieri, V;Tracy, RP;Devereux, RB
目的：评估成人2型糖尿病患者左心室肥厚（LVH）与全身炎症标志物的关系（纤维蛋白原和高敏C反应蛋白[hsCRP]）受微血管病的影响。研究设计和方法-我们使用美国糖尿病协会标准从基于人群的队列中选择患有2型糖尿病的成年人，排除有冠心病或透析依赖性肾衰竭病史或心电图证据的患者。结果：在1,299名合格的参与者中，384名（29.6%）患有LVH，单变量分析显示LVH与较高的BMI、hsCRP、纤维蛋白原和白蛋白尿相关。在控制了显著的混杂因素后，纤维蛋白原和白蛋白尿在LVH存在时更高（均P < 0.01），而hsCRP没有（P = 0.2），主要是因为BMI的混杂效应。调整蛋白尿可消除LVH与高纤维蛋白原的关系（P = 0.2）。然而，纤维蛋白原在LVH患者中显著高于无病理性蛋白尿的患者（
OBJECTIVE - To evaluate in adults with type 2 diabetes the extent to which the relation of left ventricular hypertrophy (LVH) to markers of systemic inflammation (fibrinogen and high-sensitivity C-reactive protein [hsCRP]) are affected by microangiopathy.RESEARCH DESIGN AND METHODS - We selected adults with type 2 diabetes using American Diabetes Association criteria from a population-based cohort, excluding those with medical history or electrocardiographic evidence of coronary heart disease or dialysis-dependent renal failure. LVH was assessed by echocardiogram.RESULTS - Of the 1,299 eligible participants, 384 (29.6%) had LVH, which was associated with higher BMI, hsCRP, fibrinogen, and albuminuria in univariate analyses. After controlling for significant confounders, fibrinogen and albuminuria were higher in the presence of LVH (both P < 0.01), whereas hsCRP was not (P = 0.2), mostly because of the confounding effect of BMI. Adjustment for albuminuria abolished the relation of LVH to higher fibrinogen (P = 0.2). However, fibrinogen was significantly higher in participants With LVH among those without pathologic levels of albuminuria (