High myopes have lower normalised corneal tangent moduli (less 'stiff' corneas) than low myopes
High myopes have lower normalised corneal tangent moduli (less 'stiff' corneas) than low myopes
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DOI：
10.1111/opo.12335
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发表时间：
2017-01-01
影响因子：
2.9
通讯作者：
Lam, Andrew K. C.
中科院分区：
文献类型：
--
作者：
Hon, Ying;Chen, Guo-Zhen;Lam, Andrew K. C.
目的：比较角膜切线模量之间的低，高myopes.Methods：角膜滞后（CH）和角膜阻力因子（CRF）的32个低，高myopes获得使用眼反应分析仪，然后由角膜压痕装置，测量角膜硬度。同时获得角膜地形图、角膜厚度测量、Goldmann压平眼压测量（GAT-IOP）和角膜代偿性眼压（IOPcc）。根据角膜硬度、中央角膜厚度和角膜半径计算角膜切线模量。结果：角膜切线模量与GAT-IOP（R-2 = 0.078，p = 0.025）和IOPcc（R-2 = 0.12，p = 0.006）呈正相关。尽管角膜厚度和半径相似，但高度近视患者的IOPcc（16.4 ± 2.51 mmHg）显著高于低度近视患者（13.1 ± 1.96 mmHg; t（62）=-5.57，p < 0.0001）。两组的角膜硬度（低度和高度近视分别为0.063 +/- 0.0085和0.063 +/- 0.0079 N mm（-1））和CRF（低度和高度近视分别为9.6 +/- 1.58和9.5 +/- 1.90 mmHg）相似。此外，高度近视患者的CH（9.5 ± 1.51 mmHg）显著低于低度近视患者（10.6 ± 1.38 mmHg; t（62）= 2.92，p = 0.005）。将角膜切线模量标准化为正常眼的平均眼压后，（15.5 mmHg）时，高度近视者的角膜切线模量显著降低，（0.47 +/- 0.087 MPa）比低近视（0.57 +/- 0.099 MPa; t（62）= 4.17，p < 0.0001）。结论：高度近视者的标准化角膜切线模量低于低近视者，这表明他们的角膜硬度较低。这是第一个比较不同屈光组角膜弹性模量的体内研究。进一步的研究是必要的，以了解是否较不僵硬的角膜是一个原因或近视发展的结果。
Purpose: To compare corneal tangent moduli between low and high myopes.Methods: Corneal hysteresis (CH) and corneal resistance factor (CRF) of 32 low and 32 high myopes were obtained using an Ocular Response Analyzer, followed by a corneal indentation device that measured corneal stiffness. Corneal topography, pachymetry, Goldmann applanation tonometry intraocular pressure (GAT-IOP), and corneal compensated intraocular pressure (IOPcc) were also obtained. Corneal tangent modulus was calculated on the basis of corneal stiffness, central corneal thickness and corneal radius. Comparisons between groups and associations between corneal biomechanical and ocular parameters were performed.Results: Corneal tangent moduli were positively correlated with GAT-IOP (R-2 = 0.078, p = 0.025), and IOPcc (R-2 = 0.12, p = 0.006). Despite similarity in corneal thickness and radius, high myopes exhibited a significantly higher IOPcc (16.4 +/- 2.51 mmHg) than low myopes (13.1 +/- 1.96 mmHg; t(62) = -5.57, p < 0.0001). Both groups had similar corneal stiffness (0.063 +/- 0.0085 and 0.063 +/- 0.0079 N mm(-1) for low and high myopes, respectively) and CRF (9.6 +/- 1.58 and 9.5 +/- 1.90 mmHg for low and high myopes, respectively). Moreover, high myopes exhibited a significantly lower CH (9.5 +/- 1.51 mmHg) than low myopes (10.6 +/- 1.38 mmHg; t(62) = 2.92, p = 0.005). After normalising corneal tangent moduli to the mean intraocular pressure in normal eyes (15.5 mmHg) using IOPcc, high myopes showed a significantly lower corneal tangent moduli (0.47 +/- 0.087 MPa) than low myopes (0.57 +/- 0.099 MPa; t(62) = 4.17, p < 0.0001).Conclusions: High myopes had lower normalised corneal tangent moduli than low myopes, which indicated that their corneas were less stiff. This is the first in vivo study comparing elastic moduli of the cornea in different refractive groups. Further studies are warranted to understand whether a less stiff cornea is a cause for or an outcome from myopia development.